{
  "abstract": "DNA polymerase ζ (Polζ) has emerged as a key reverse transcriptase in RNA-templated double-strand break repair (RT-DSBR), beyond its canonical role in translesion DNA synthesis (TLS). We present here the cryo-EM structure of yeast Polζ (including Rev1) in the act of reverse transcription, wherein the polymerase molds the replicative end of the bound RNA:DNA hybrid into B-like conformation and retains most contacts seen with DNA:DNA. Critically, the polymerase adopts the same conformation as with DNA:DNA, indicating its inherent versatility in accommodating both DNA:DNA and RNA:DNA substrates to preserve genome stability.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY USA",
    "Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Radhika Malik",
      "orcid": "0000-0002-6752-7056"
    },
    {
      "affs": [
        1
      ],
      "name": "Robert E. Johnson",
      "orcid": "0000-0002-6809-7123"
    },
    {
      "affs": [
        1
      ],
      "name": "Louise Prakash"
    },
    {
      "affs": [
        1
      ],
      "name": "Satya Prakash",
      "orcid": "0000-0001-7228-1444"
    },
    {
      "affs": [
        0
      ],
      "name": "Aneel K. Aggarwal",
      "orcid": "0000-0003-4389-0173"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e23zsk6mebxky.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78032-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696706/",
  "id": "e23zsk6mebxky",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-78032-8",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|DNA Repair Mechanisms"
    ]
  ],
  "openalex": "W7214303607",
  "pdf_url": "https://europepmc.org/articles/PMC13696706?pdf=render",
  "pmcid": "PMC13696706",
  "pmid": "42928375",
  "published": "2026-09-25",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/e23zsk6mebxky.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:01Z",
      "native_id": "PMC13696706",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-78032-8"
    },
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928375",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928375"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|DNA Repair Mechanisms",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Molecular basis of DNA polymerase ζ’s reverse transcriptase activity",
  "title_text": "Molecular basis of DNA polymerase ζ’s reverse transcriptase activity",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:00Z",
  "url": "https://research.draconitic.com/paper/e23zsk6mebxky",
  "venue": "Nature Communications",
  "versions": []
}