{
  "abstract": "BackgroundThe imprecision of current metrics to capture the complex genetic admixture and racial identity among Hispanic/Latino individuals in the United States (US) is a concern. We examined the relationship of self-reported race and genetic ancestry with hypertension (HTN) among Hispanics/Latinos.\n\nMethodsCross-sectional study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), including 10,586 Hispanic/Latino unrelated adults. Genetic ancestry: West African (AA), Amerindian (AI), and European (EA). Self-reported race: White, Black, Native American, or Multiple/Missing (More than one race or Unknown/Not reported/Refused). HTN: systolic (SBP) [≥]130 mmHg, diastolic blood pressure (DBP) [≥]80 mmHg, and/or use of HTN medications. Age- and sex adjusted models were used.\n\nResultsSelf-reported race was White (38{middle dot}6%), Black (3{middle dot}6%), Native American (4{middle dot}1%), and Multiple/Missing (53{middle dot}7%), with Unknown/Not reported/Refused representing 32{middle dot}7%. Black and White Hispanics/Latinos had the greatest AA (55{middle dot}7%) and EA (69{middle dot}3%) ancestries, respectively. Each 10% AA increase was associated with OR 1{middle dot}15, SBP beta +0.9 mmHg, and DBP beta +0.7 mmHg. Conversely, each 10% AI increase was associated with OR 0{middle dot}83, SBP beta -0{middle dot}4 mmHg, and DBP beta -0{middle dot}6 mmHg. HTN prevalence was highest among those with Black race or in the highest AA quantile (45{middle dot}6% and 48{middle dot}0%, respectively), and lowest among those with Native American race or in the highest AI quantile (37{middle dot}6% and 26{middle dot}7%, respectively).\n\nConclusionOne-third of Hispanics/Latinos did not self-report race. Black or White self-reporting race did somewhat relate to AA or EA ancestry, respectively. HTN profiles were related to self-reported race and genetic ancestry in this admixed population.",
  "abstract_shown": true,
  "affiliations": [
    "Montefiore Medical Group"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "R. A. Montanez-Valverde"
    },
    {
      "name": "V. Kim"
    },
    {
      "name": "P. Duran-Luciano"
    },
    {
      "name": "Y. Yuan"
    },
    {
      "name": "T. Sofer"
    },
    {
      "name": "R. C. Kaplan"
    },
    {
      "name": "L. C. Gallo"
    },
    {
      "name": "G. A. Talavera"
    },
    {
      "name": "K. M. Perreira"
    },
    {
      "name": "M. L. Daviglus"
    },
    {
      "name": "S. E. Rosas"
    },
    {
      "name": "M. M. Llabre"
    },
    {
      "name": "T. Elfassy"
    },
    {
      "name": "X. Li"
    },
    {
      "name": "C. R. Isasi"
    },
    {
      "name": "C. J. Rodriguez"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e2hgj8meesw5s.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.01.26361995",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.01.26361995v1.full",
  "id": "e2hgj8meesw5s",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.01.26361995v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "genetic and genomic medicine"
    ],
    [
      "openalex",
      "2705|Blood Pressure and Hypertension Studies"
    ]
  ],
  "openalex": "W7208736778",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.01.26361995v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e2hgj8meesw5s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.64898/2026.09.01.26361995",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.01.26361995v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:genetic and genomic medicine",
      "subfield": "human-genetics"
    }
  ],
  "title": "Relation of Self-Reported Race and Genetic Ancestry to Hypertension Prevalence Among Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos",
  "title_text": "Relation of Self-Reported Race and Genetic Ancestry to Hypertension Prevalence Among Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/e2hgj8meesw5s",
  "venue": "medRxiv",
  "versions": []
}