{
  "abstract": "The interferon (IFN)-inducible RNA editor ADAR1 p150 catalyzes adenosine-to-inosine (A-to-I) editing of host and viral double-stranded RNAs, limiting aberrant innate immune sensing and regulating gene expression. How ADAR1 p150 activity is regulated during host-virus interactions remains poorly understood. Here, we identify the IFN-stimulated gene OASL as an inhibitor of ADAR1 p150. OASL engages p150 through two distinct interactions: its N-terminal OAS domain associates with the RNA-binding domains in an RNA-dependent manner, whereas its C-terminal ubiquitin-like domains bind the Z domain independently of RNA. Despite their distinct canonical functions, the OAS and ubiquitin-like domains converge to limit ADAR1 p150 RNA binding and suppress A-to-I editing across the transcriptome. OASL also reverses p150-mediated suppression of antiviral and innate immune gene expression and counteracts p150-mediated enhancement of measles virus and vesicular stomatitis virus replication. Thus, OASL restrains ADAR1 p150, linking interferon signaling to the control of RNA editing and antiviral immunity.",
  "abstract_shown": true,
  "affiliations": [
    "Cleveland Clinic Research"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "S. Leon Quinonez"
    },
    {
      "name": "A. Gupta"
    },
    {
      "name": "S. Kang"
    },
    {
      "name": "Z. Jiang"
    },
    {
      "name": "C. C. Hsu"
    },
    {
      "name": "J. Li"
    },
    {
      "name": "F. Cheng"
    },
    {
      "affs": [
        0
      ],
      "name": "J. Jung"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e2p00qxbxhs26.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.05.756717",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756717v1.full",
  "id": "e2p00qxbxhs26",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756717v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "molecular biology"
    ],
    [
      "openalex",
      "1312|RNA regulation and disease"
    ]
  ],
  "openalex": "W7220656470",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756717v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e2p00qxbxhs26.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:11Z",
      "native_id": "10.64898/2026.10.05.756717",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756717v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Interferon-induced OASL restricts ADAR1 p150 RNA binding and A-to-I RNA editing",
  "title_text": "Interferon-induced OASL restricts ADAR1 p150 RNA binding and A-to-I RNA editing",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:11Z",
  "url": "https://research.draconitic.com/paper/e2p00qxbxhs26",
  "venue": "bioRxiv",
  "versions": []
}