{
  "abstract": "A mild and efficient indium-catalyzed coupling of propargylamines with terminal alkynes has been developed, affording a diverse array of conjugated 1,3-dienones in good to excellent yields. The reaction proceeds via in situ hydrolysis of propargylamines to generate the corresponding enones, followed by an indium(III)-promoted syn-selective alkyne insertion. Using InCl3 as the catalyst and DBU as the base, the protocol features broad functional-group tolerance and operates under mild conditions. Mechanistic investigations indicate that indium activation is crucial for facilitating the addition of alkynes to enones, enabling selective construction of conjugated 1,3-dienones frameworks. This transformation represents a rare example of indium-catalyzed C–C bond formation and provides a practical and versatile approach to structurally diverse 1,3-dienones from readily available propargylamine precursors.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, Belgium, B-3001",
    "College of Chemistry and Chemical Engineering",
    "Shanghai University of Engineering Science",
    "Peoples’ Friendship University of Russia (RUDN University, Miklukho-Maklaya Street 6, Moscow, Russia, 117198"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yujuan Xie",
      "orcid": "0009-0008-9746-2610"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Liliang Huang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Huangdi Feng"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Erik V. Van der Eycken"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e2r9h3f18hvdy.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010187/v1",
  "fulltext_url": null,
  "id": "e2r9h3f18hvdy",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010187/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Catalytic Alkyne Reactions"
    ]
  ],
  "openalex": "W7221067657",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010187/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/e2r9h3f18hvdy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15010187",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010187/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic Alkyne Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Indium-Catalyzed Deaminative Coupling of Propargylamines with Terminal Alkynes: A Mild Approach to Conjugated 1,3-Dienones",
  "title_text": "Indium-Catalyzed Deaminative Coupling of Propargylamines with Terminal Alkynes: A Mild Approach to Conjugated 1,3-Dienones",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/e2r9h3f18hvdy",
  "venue": "ChemRxiv",
  "versions": []
}