{
  "abstract": "Natural polyphenols exert multi-target hepatoprotective activities via orchestrating hepatic redox homeostasis, lipid metabolism, and hepatic innate-adaptive immune responses, yet their clinical and food-grade translation is hampered by poor stability, low bioavailability and dose-dependent safety risks. This review integrates polyphenol classification with critical toxicological analysis to address pro-oxidant, endocrine-disrupting, and immune-perturbing hazards under high-dose supplementation. We systematically construct multipathway hepatoprotective networks, highlighting polyphenol-driven immunomodulatory effects including macrophage polarization, NLRP3 inflammasome repression, and immunometabolic reprogramming, alongside classical antioxidant, anti-inflammatory, lipid-homeostasis-regulating, anti-pyroptotic, anti-apoptotic and antifibrotic outputs. Four stabilization-delivery approaches are assessed, alongside key bottlenecks including crude extract batch variation, incomplete recognition of gut-liver immune crosstalk, costly nanocarriers and deficient quantitative immune-phenotyping evaluation systems. An integrated strategy combining molecular modification, green stabilization, hepatocyte-/immune-cell-responsive delivery and therapeutic-efficacy traceability is proposed to advance polyphenol-based hepatoprotective candidates for immune-mediated liver injury.",
  "abstract_shown": true,
  "affiliations": [
    "Jilin University Engineering Laboratory for Translational Medicine of Hepatobiliary and Pancreatic Diseases, The Second Norman Bethune Clinical Medical College of Jilin University",
    "College of Food Science and Engineering, Jilin Agricultural University"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaoxiao Yao"
    },
    {
      "affs": [
        1
      ],
      "name": "Ruining Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yi Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi’en Xiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e2rjpkcz21qvk.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1988758",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1988758/full",
  "id": "e2rjpkcz21qvk",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1988758/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC581-607"
    ],
    [
      "openalex",
      "2704|Phytochemicals and Antioxidant Activities"
    ]
  ],
  "openalex": "W7223378335",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1988758/pdf",
  "pmcid": "PMC13740496",
  "pmid": "42996515",
  "published": "2026-10-23",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/e2rjpkcz21qvk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1988758",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1988758/full"
    },
    {
      "first_seen": "2026-10-30T13:43:54Z",
      "native_id": "4d90defa9f9748a49669f0d0d8aab7b8",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fimmu.2026.1988758"
    },
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42996515",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996515"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    },
    {
      "field": "medicine",
      "origin": "lcc:RC581-607",
      "subfield": "general"
    }
  ],
  "title": "Hepatoprotective natural polyphenol extracts: molecular mechanisms, stabilization-delivery strategies, and translational bottlenecks for functional food applications",
  "title_text": "Hepatoprotective natural polyphenol extracts: molecular mechanisms, stabilization-delivery strategies, and translational bottlenecks for functional food applications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/e2rjpkcz21qvk",
  "venue": "Frontiers in Immunology",
  "versions": []
}