{
  "abstract": "Objectives\n\nTo examine demographic and socioeconomic differences in diagnosis and treatment of neuroma and nerve injury, assess risk of long-term use of centrally acting analgesics (CA-analgesics) compared with the general population, and describe how long-term use is distributed among individuals by demographic, socioeconomic, and treatment characteristics.Methods\n\nIn linked Swedish national registers (5,625,751 individuals, 25-80 years, residing 2010), incident cases of nonsurgically or surgically treated neuromas (n = 608' n = 189, respectively) or nerve injuries (n = 3,719, n = 2,122, respectively) were identified (no clinical data available) 2011 to 2014 and long-term CA-analgesic use was defined (prescription coverage ≥60% of days during 1 year; 60-day washout period after surgery). Multinomial and binary logistic regression models were used to estimate relative risks, adjusted for sex, age, income level, country of birth, and cohabiting. Absolute risks and absolute risk differences were calculated.Results\n\nNeuroma or nerve injury cases were identified with variation in diagnosis and treatment by demographic and socioeconomic factors; women more likely to undergo neuroma surgery; men and younger individuals predominated among nerve injuries. All diagnostic treatment groups had markedly increased risks of long-term CA-analgesic use compared with the general population (adjusted relative risk range 3.5-6.0). Absolute risks among individuals exceeded 10% in socioeconomically disadvantaged subgroups (approximately 0.5% in the general population). Differences in long-term CA-analgesic use between nonsurgically and surgically treated individuals were modest.Conclusions\n\nNeuroma and nerve injuries are associated with a substantial risk of long-term CA-analgesic use. Socioeconomic disadvantage strongly influences risk, whereas surgical treatment does not consistently reduce long-term medication use.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Translational Medicine-Hand Surgery, Lund University, Skåne University Hospital, Malmö, Sweden.",
    "Department of Orthopedics, Helsingborg Hospital, Helsingborg, Sweden.",
    "Unit for Social Epidemiology, Department of Clinical Sciences (Malmö), Faculty of Medicine, Lund University, Malmö, Sweden.",
    "Center for Primary Health Research, Region Skåne, Malmö, Sweden.",
    "Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.",
    "Department of Orthopedic and Hand Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.",
    "Department of Hand Surgery, Skåne University Hospital, Malmö, Sweden."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Emma Dahlin",
      "orcid": "0009-0009-2536-9190"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Raquel Perez"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Malin Zimmerman"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Juan Merlo"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Erika Nyman"
    },
    {
      "affs": [
        0,
        1,
        4,
        6
      ],
      "name": "Lars B Dahlin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e2wx8xbh0vdzc.bib",
  "cited_by": 0,
  "doi": "10.1097/pr9.0000000000001511",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719113/?tool=EBI",
  "id": "e2wx8xbh0vdzc",
  "issns": [
    "2471-2531"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13719113",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Neuropathic"
    ],
    [
      "heading",
      "Research Paper"
    ],
    [
      "openalex",
      "2739|Opioid Use Disorder Treatment"
    ]
  ],
  "openalex": "W7224804832",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719113/pdf/?tool=EBI",
  "pmcid": "PMC13719113",
  "pmid": "42960349",
  "published": "2026-10-28",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/e2wx8xbh0vdzc.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13719113",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13719113"
    },
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42960349",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960349"
    },
    {
      "first_seen": "2026-11-02T12:23:00Z",
      "native_id": "PMC13719113",
      "source": "pmc",
      "url": "https://doi.org/10.1097/pr9.0000000000001511"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Opioid Use Disorder Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Long-term analgesic use after neuroma and upper limb nerve injury: patterns in Sweden",
  "title_text": "Long-term analgesic use after neuroma and upper limb nerve injury: patterns in Sweden",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:23:00Z",
  "url": "https://research.draconitic.com/paper/e2wx8xbh0vdzc",
  "venue": "Pain reports",
  "versions": []
}