{
  "abstract": "Herein, we describe the use of IR irradiation to promote Pd‐catalyzed C(sp3)─H arylation and tandem C(sp3)─H arylation/electrophilic aromatic cyclization of ortho‐tolualdehydes with aryl iodides via a transient directing group (TDG) strategy. The optimized conditions employ Pd(OAc)2 (10 mol%) as the catalyst, glycine (40 mol%) as the TDG, and AgTFA (1.5 equiv.) as the additive in an AcOH/H2O (9:1, v/v) solvent mixture under irradiation with a 250 W IR lamp. The reaction time (30 min) is considerably shorter than previously reported reaction times for similar reactions performed under thermal heating (12–48 h, 90°C–130°C). The reaction outcome under infrared (IR) irradiation strongly depends on the electronic nature of the substituents on the aryl iodides: electron‐withdrawing groups at any position and electron‐donating groups at the ortho and/or para positions favor the Pd‐catalyzed C(sp3)─H arylation, leading to 2‐benzylbenzaldehydes, whereas, in the presence of electron‐donating groups at the meta‐position, a tandem C(sp3)─H arylation/electrophilic aromatic cyclization occurs, producing substituted anthracenes.",
  "abstract_shown": true,
  "affiliations": [
    "Dipartimento Di Chimica Università Degli Studi di Bari Aldo Moro Bari Italy",
    "Dipartimento Di Scienze Chimiche, Della Vita e della Sostenibilità Ambientale Università Di Parma Parma Italy"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Matteo Renato Martina"
    },
    {
      "affs": [
        0
      ],
      "name": "Ambra Maria Fiore",
      "orcid": "0000-0002-9882-0757"
    },
    {
      "affs": [
        0
      ],
      "name": "Angela Punzi",
      "orcid": "0000-0001-5948-6373"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gianluigi Albano",
      "orcid": "0000-0002-2466-5598"
    },
    {
      "affs": [
        0
      ],
      "name": "Roberta Ragni",
      "orcid": "0000-0002-0451-7096"
    },
    {
      "affs": [
        0
      ],
      "name": "Pietro Cotugno",
      "orcid": "0000-0002-6487-9152"
    },
    {
      "affs": [
        0
      ],
      "name": "Gianluca Maria Farinola",
      "orcid": "0000-0002-1601-2810"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e2zkrpgmkbwzt.bib",
  "cited_by": 0,
  "doi": "10.1002/chem.71564",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729939/",
  "id": "e2zkrpgmkbwzt",
  "issns": [
    "0947-6539",
    "1521-3765"
  ],
  "landing_url": "https://doi.org/10.1002/chem.71564",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1605|Catalytic C–H Functionalization Methods"
    ]
  ],
  "openalex": "W7202260939",
  "pdf_url": null,
  "pmcid": "PMC13729939",
  "pmid": "42581711",
  "published": "2026-08-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e2zkrpgmkbwzt.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:39Z",
      "native_id": "PMC13729939",
      "source": "pmc",
      "url": "https://doi.org/10.1002/chem.71564"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic C–H Functionalization Methods",
      "subfield": "organic"
    }
  ],
  "title": "Infrared Irradiation‐Assisted Pd‐Catalyzed C(sp3)─H Arylation and Tandem Cyclization of Ortho‐Tolualdehydes",
  "title_text": "Infrared Irradiation‐Assisted Pd‐Catalyzed C(sp3)─H Arylation and Tandem Cyclization of Ortho‐Tolualdehydes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:39Z",
  "url": "https://research.draconitic.com/paper/e2zkrpgmkbwzt",
  "venue": "Chemistry (Weinheim an Der Bergstrasse, Germany)",
  "versions": []
}