{
  "abstract": "Background: The widespread exposure to acrylamide from diet and tobacco smoke during prenatal development is of concern as acrylamide is neurotoxic and potentially contributes to the development of neuropsychiatric disorders. We aimed to examine associations between prenatal acrylamide exposure and neuropsychiatric outcomes.\n\nMethods: In this biomarker-based study of offspring from the Danish Foetal Origins 1988–1989 birth cohort, pregnant women were enrolled at gestational week 30 at a routine antenatal clinic at Aarhus Hospital, Denmark. Liveborn singletons with available exposure and outcome data were included. The current study was conducted from 2022 to 2026. Prenatal acrylamide exposure was quantified using haemoglobin adducts (HbAA) in maternal blood collected during pregnancy. Incident cases of depression, anxiety, attention-deficit/hyperactivity disorder (ADHD), co-occurring ADHD and autism spectrum disorder (ASD), as a composite outcome, and any neuropsychiatric disorders were identified from national diagnostic and prescription registries in the first 34 years of life (1988–2023). The associations were estimated using adjusted log-linear Poisson regression models.\n\nFindings: Among 861 offspring, 146 cases of depression, 72 of anxiety, 45 of ADHD, 53 of co-occurring ADHD and ASD, and 150 cases of any neuropsychiatric diagnosis occurred during follow-up. Median (P5–P95) HbAA was 93 (45–250) pmol/g Hb and maternal active smoking during pregnancy was common (42%). Each 10-pmol/g Hb increase in HbAA was associated with IRRs of 1.02 (95% CI 0.99–1.05) for depression and 1.03 (0.99–1.07) for anxiety. High vs. low exposure (≥P75 = 146 pmol/g Hb, vs. <P75) was associated with increased risks of depression (IRR 1.64, 1.05–2.56) and anxiety (IRR 2.29, 1.23–4.25). The estimates for ADHD (1.56, 0.73–3.32), co-occurring ADHD and ASD (1.49, 0.73–3.02) and any neuropsychiatric diagnosis (1.41, 0.90–2.22) showed non-significant increased risk.\n\nInterpretation: The findings support an association between prenatal acrylamide exposure and increased incidence of depression and anxiety in adolescence and adulthood. These findings require replication in cohorts with repeated exposure measurements of a range of dietary exposures to establish to what extent the prenatal exposure to acrylamide was responsible for the observed associations.\n\nFunding: 10.13039/501100000781European Research Council, 10.13039/100012774Innovation Fund Denmark, 10.13039/100007398Danish Council for Strategic Research and 10.13039/501100009244Stockholm University.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Damian Chandia-Poblete",
      "orcid": "0000-0003-3081-784X"
    },
    {
      "name": "Stéphane Tuffier",
      "orcid": "0000-0003-1969-2070"
    },
    {
      "name": "Efstathios Vryonidis"
    },
    {
      "name": "Thorhallur Ingi Halldorsson"
    },
    {
      "name": "Anne Ahrendt Bjerregaard"
    },
    {
      "name": "Marin Strøm",
      "orcid": "0000-0003-1926-6610"
    },
    {
      "name": "Dorte Rytter"
    },
    {
      "name": "Bodil Hammer Bech"
    },
    {
      "name": "Tine Brink Henriksen",
      "orcid": "0000-0001-6933-8294"
    },
    {
      "name": "Sjurdur Frodi Olsen"
    },
    {
      "name": "Margareta Törnqvist"
    },
    {
      "name": "Marie Pedersen",
      "orcid": "0000-0002-9930-0446"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e3cmnhmehnhjc.bib",
  "cited_by": 0,
  "doi": "10.1016/j.eclinm.2026.104286",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734943/",
  "id": "e3cmnhmehnhjc",
  "issns": [
    "2589-5370"
  ],
  "landing_url": "https://linkinghub.elsevier.com/retrieve/pii/S2589537026005390",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Articles"
    ],
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      "openalex",
      "1106|Potato Plant Research"
    ]
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  "openalex": "W7223705819",
  "pdf_url": null,
  "pmcid": "PMC13734943",
  "pmid": "42990972",
  "published": "2026-10-26",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/e3cmnhmehnhjc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:48Z",
      "native_id": "10.1016/j.eclinm.2026.104286",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589537026005390"
    },
    {
      "first_seen": "2026-11-09T12:20:44Z",
      "native_id": "PMC13734943",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.eclinm.2026.104286"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Prenatal exposure to acrylamide and neuropsychiatric disorders: a biomarker-based birth cohort study with 34 years of follow-up",
  "title_text": "Prenatal exposure to acrylamide and neuropsychiatric disorders: a biomarker-based birth cohort study with 34 years of follow-up",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:44Z",
  "url": "https://research.draconitic.com/paper/e3cmnhmehnhjc",
  "venue": "eClinicalMedicine",
  "versions": []
}