{
  "abstract": "Introduction: Progressive hearing loss (PHL) in childhood can significantly impact speech, language, and educational outcomes. While congenital and acquired aetiological factors for PHL are well documented, their influence on hearing deterioration and the trajectory of PHL remains unclear. Understanding prognostic factors is essential to enable targeted surveillance and timely intervention.\n\nMethods: A PROSPERO-registered systematic review (ID: CRD42023492129) was conducted to identify and evaluate prognostic factors associated with childhood PHL. MEDLINE, EMBASE, and Cochrane Library databases were searched for studies published between 2000 and 2025 in English, including patients aged 0–18 years, with confirmed permanent hearing loss. Study design quality was assessed using CHARMS-PF, and risk of bias was evaluated with QUIPS (Quality in Prognosis Factor Studies). Due to heterogeneity in definitions and outcomes, a narrative synthesis was performed.\n\nResults: Eighteen (participants n = 1,497) studies were included in the narrative synthesis and eligible for risk of bias assessment; only 2 were deemed low risk. Exploratory prognostic factors included congenital cytomegalovirus infection, enlarged vestibular aqueduct, platinum-based chemotherapy, and radiotherapy. The influence of these factors on the rate and severity of hearing loss was variable, and current evidence was insufficient for meta-analysis or definitive prognostic conclusions.\n\nConclusion: Evidence on prognostic factors for PHL is limited and heterogeneous. High-quality, methodologically robust studies are needed to confirm these factors and develop predictive, multivariable models. Such models could guide personalised surveillance and intervention strategies, enabling clinicians to deliver the right intervention at the optimal time and improving long-term auditory and developmental outcomes for children at risk of PHL.",
  "abstract_shown": true,
  "affiliations": [
    "Audiology Department, Imperial College Healthcare NHS Trust, London, UK",
    "Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK",
    "Paediatric ENT Department, Royal Manchester Children’s Hospital, Manchester University NHS Foundation Trust, Manchester, UK",
    "Manchester University NHS Foundation Trust, Manchester, UK",
    "Hearing Health Theme, NIHR Manchester Biomedical Research Centre, University of Manchester, Manchester, UK"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "James Dempsey"
    },
    {
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        2
      ],
      "name": "Nathan Richard Walker"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Michael Lawrence"
    },
    {
      "affs": [
        3
      ],
      "name": "Callum Shields"
    },
    {
      "affs": [
        1
      ],
      "name": "Glen P. Martin"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Karolina Kluk"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Iain A. Bruce"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Jaya R. Nichani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e3qja12ae0t2t.bib",
  "cited_by": 0,
  "doi": "10.1159/aud/abnag013",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722465/",
  "id": "e3qja12ae0t2t",
  "issns": [
    "1420-3030",
    "1421-9700"
  ],
  "landing_url": "https://doi.org/10.1159/aud/abnag013",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Systematic Review"
    ],
    [
      "openalex",
      "2805|Hearing Loss and Rehabilitation"
    ]
  ],
  "openalex": "W7220667234",
  "pdf_url": "https://karger.com/aud/article-pdf/doi/10.1159/aud/abnag013/4591480/000554546.pdf",
  "pmcid": "PMC13722465",
  "pmid": "42832432",
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e3qja12ae0t2t.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:22:57Z",
      "native_id": "PMC13722465",
      "source": "pmc",
      "url": "https://doi.org/10.1159/aud/abnag013"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Hearing Loss and Rehabilitation",
      "subfield": "neuroscience"
    }
  ],
  "title": "Progressive Hearing Loss in Childhood: A Prognostic Factor Systematic Review",
  "title_text": "Progressive Hearing Loss in Childhood: A Prognostic Factor Systematic Review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:57Z",
  "url": "https://research.draconitic.com/paper/e3qja12ae0t2t",
  "venue": "Audiology & Neurotology",
  "versions": []
}