{
  "abstract": "Objectives: The present study evaluated the antimicrobial activity of extracts from five Cameroonian medicinal plants against planktonic forms of Helicobacter pylori isolates and assessed their ability to inhibit biofilm formation and eradicate preformed biofilms.\n\nMethods: The antimicrobial activity of 15 extracts obtained from Psidium guajava leaves, Mangifera indica leaves, Cymbopogon citratus aerial parts, Musa ‘False Horn’ ripe fruit peelings, and Syzygium aromaticum flower buds was evaluated against 48 planktonic forms of H. pylori clinical isolates using the broth microdilution method. The inhibition of biofilm formation and eradication of preformed biofilms were evaluated using the crystal violet staining assay.\n\nResults: The hexane extract of M. indica leaves exhibited the strongest antibacterial activity, with minimum inhibitory concentration values ranging from 31.25 to 62.5 μg/mL against 3/48 (6.25%) of the tested isolates. The lowest minimum biofilm inhibition concentration (MBIC) of 62.5 μg/mL was obtained with the methanol extract of Musa ‘False Horn’ fruit peelings and the dichloromethane extract of P. guajava leaves. The lowest minimum biofilm eradication concentration (MBEC) of 125 μg/mL was recorded for the hexane extract of P. guajava leaves and the methanol extract of Musa ‘False Horn’ fruit peelings.\n\nConclusion: The investigated plant extracts exhibited antibacterial activity against planktonic H. pylori, whereas several extracts also demonstrated promising antibiofilm activity. These findings support further phytochemical characterization, toxicity evaluation, and in vivo studies to investigate their potential as complementary therapeutic agents against H. pylori infections.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Microbiology and Antimicrobial Substances Laboratory Biotechnology Center University of Yaoundé Yaoundé Cameroon uninet.cm"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Keuna Ngounou Cyrielle Almeida"
    },
    {
      "affs": [
        0
      ],
      "name": "Kouitcheu Mabeku Laure Brigitte",
      "orcid": "0000-0002-6447-1413"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e4nj3r4hdbfy3.bib",
  "cited_by": 0,
  "doi": "10.1155/bmri/1930477",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715488/",
  "id": "e4nj3r4hdbfy3",
  "issns": [
    "2314-6133",
    "2314-6141"
  ],
  "landing_url": "https://doi.org/10.1155/bmri/1930477",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2746|Helicobacter pylori-related gastroenterology studies"
    ]
  ],
  "openalex": "W7224108561",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/bmri/1930477",
  "pmcid": "PMC13715488",
  "pmid": "42949297",
  "published": "2026-10-28",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/e4nj3r4hdbfy3.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:47Z",
      "native_id": "PMC13715488",
      "source": "pmc",
      "url": "https://doi.org/10.1155/bmri/1930477"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Helicobacter pylori-related gastroenterology studies",
      "subfield": "surgery"
    }
  ],
  "title": "Anti‐Helicobacter pylori Activity of Musa ‘False Horn’ (Musaceae), Syzygium aromaticum (Myrtaceae), Psidium guajava (Myrtaceae), Mangifera indica (Anacardiaceae), and Cymbopogon citratus (Poaceae) and Their Potential to Prevent and Eradicate H. pylori Biofilms",
  "title_text": "Anti‐Helicobacter pylori Activity of Musa ‘False Horn’ (Musaceae), Syzygium aromaticum (Myrtaceae), Psidium guajava (Myrtaceae), Mangifera indica (Anacardiaceae), and Cymbopogon citratus (Poaceae) and Their Potential to Prevent and Eradicate H. pylori Biofilms",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:47Z",
  "url": "https://research.draconitic.com/paper/e4nj3r4hdbfy3",
  "venue": "BioMed Research International",
  "versions": []
}