{
  "abstract": "The release of bacterial bioactive molecules across the gut barrier is a crucial yet poorly understood step in host-microbe communication. Here, we identify a phage-driven mechanism associated with this process in the beneficial symbiont Lactiplantibacillus plantarum NC8 (LpNC8). We show that a stress-responsive prophage, pp2, undergoes activation and triggers holin-lysin-mediated bacterial lysis, leading to the production of infectious phage particles and increased extracellular recovery of bacterial vesicles carrying lipoteichoic acids. In a model of nutritional symbiosis, pp2-dependent lysis is required for LpNC8 to promote juvenile growth in undernourished Drosophila melanogaster. Disruption of prophage-mediated lysis impairs vesicle recovery and host growth promotion. Furthermore, we demonstrate that the copper cell region of the Drosophila midgut acts as a physiological trigger of prophage induction. Together, our findings link host intestinal physiology to prophage activity and bacterial lysis, revealing phage-driven lysis as a mechanism contributing to beneficial bacterial-host interactions during nutritional stress.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Chenxu Zhu",
      "orcid": "0009-0006-4069-1047"
    },
    {
      "name": "Sylvie Manuse",
      "orcid": "0000-0002-8749-7018"
    },
    {
      "name": "Quentin Perrier",
      "orcid": "0009-0004-7343-7120"
    },
    {
      "name": "Subhasree Venkatasubramaniyan",
      "orcid": "0009-0001-8378-3738"
    },
    {
      "name": "Houssam Akherraz",
      "orcid": "0000-0001-8325-1179"
    },
    {
      "name": "Norbert Lodej"
    },
    {
      "name": "Cathy I. Ramos",
      "orcid": "0000-0001-8378-5277"
    },
    {
      "name": "Meiling Zhang"
    },
    {
      "name": "Christophe Grangeasse",
      "orcid": "0000-0002-5484-4589"
    },
    {
      "name": "Agnieszka Razim",
      "orcid": "0000-0001-5471-7013"
    },
    {
      "name": "François Leulier",
      "orcid": "0000-0002-4542-3053"
    },
    {
      "name": "Renata C. Matos",
      "orcid": "0000-0001-7480-6099"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e53960kwbd1wv.bib",
  "cited_by": 0,
  "doi": "10.1016/j.celrep.2026.118110",
  "fulltext_url": null,
  "id": "e53960kwbd1wv",
  "issns": [
    "2211-1247",
    "2211-1247"
  ],
  "landing_url": "https://hal.science/hal-05788076v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2303|Bacteriophages and microbial interactions"
    ]
  ],
  "openalex": "W7221049737",
  "pdf_url": "https://hal.science/hal-05788076/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Elsevier Inc",
  "ris": "https://research.draconitic.com/paper/e53960kwbd1wv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:52Z",
      "native_id": "hal-05788076",
      "source": "hal",
      "url": "https://hal.science/hal-05788076v1"
    },
    {
      "first_seen": "2026-10-30T12:19:34Z",
      "native_id": "10.1016/j.celrep.2026.118110",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2211124726011897"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2303|Bacteriophages and microbial interactions",
      "subfield": "ecology"
    }
  ],
  "title": "Host-triggered prophage induction drives Lactiplantibacillus plantarum symbiosis through bacterial lysis",
  "title_text": "Host-triggered prophage induction drives Lactiplantibacillus plantarum symbiosis through bacterial lysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:34Z",
  "url": "https://research.draconitic.com/paper/e53960kwbd1wv",
  "venue": "Cell Reports",
  "versions": []
}