{
  "abstract": "Vasoactive intestinal peptide (VIP)-secreting tumors are rare neuroendocrine neoplasms that cause severe secretory diarrhea and electrolyte abnormalities. We describe 2 atypical cases requiring multidisciplinary care. One patient had a VIP-secreting pheochromocytoma with elevated VIP and metanephrine levels; symptoms improved after adrenalectomy. The second had a metastatic small intestinal neuroendocrine tumor with persistent VIP-mediated diarrhea despite debulking and somatostatin analog therapy, complicated by anal fissures, trans-sphincteric perianal fistula, and neuropathic pelvic pain. These cases highlight morbidity and potential complications associated with extrapancreatic VIP hypersecretion and the value of coordinated multidisciplinary management to improve outcomes and quality of life.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, University of Illinois College of Medicine Peoria, Peoria, IL.",
    "Department of Gastroenterology and Hepatology, University of Illinois College of Medicine Peoria, Peoria, IL."
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yusuf Kagzi"
    },
    {
      "affs": [
        1
      ],
      "name": "Fatima Ahson"
    },
    {
      "affs": [
        1
      ],
      "name": "Nikhil Kalva"
    },
    {
      "affs": [
        1
      ],
      "name": "Imran L Balouch"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e560y06rk46y8.bib",
  "cited_by": 0,
  "doi": "10.14309/crj.0000000000002382",
  "fulltext_url": "https://europepmc.org/articles/PMC13716408",
  "id": "e560y06rk46y8",
  "issns": [
    "2326-3253"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953880",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "heading",
      "Small Bowel"
    ],
    [
      "openalex",
      "2713|Neuroendocrine Tumor Research Advances"
    ]
  ],
  "openalex": "W7224119541",
  "pdf_url": "https://europepmc.org/articles/PMC13716408?pdf=render",
  "pmcid": "PMC13716408",
  "pmid": "42953880",
  "published": "2026-10-28",
  "publisher": "American College of Gastroenterology",
  "ris": "https://research.draconitic.com/paper/e560y06rk46y8.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:40Z",
      "native_id": "MED:42953880",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953880"
    },
    {
      "first_seen": "2026-11-01T12:23:24Z",
      "native_id": "PMC13716408",
      "source": "pmc",
      "url": "https://doi.org/10.14309/crj.0000000000002382"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Neuroendocrine Tumor Research Advances",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "VIP-Mediated Syndromes: Contrasting Presentations and Multidisciplinary Management of Two Rare Neuroendocrine Tumors.",
  "title_text": "VIP-Mediated Syndromes: Contrasting Presentations and Multidisciplinary Management of Two Rare Neuroendocrine Tumors.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:24Z",
  "url": "https://research.draconitic.com/paper/e560y06rk46y8",
  "venue": "ACG case reports journal",
  "versions": []
}