{
  "abstract": "Background: Uterine immature teratoma is an extremely rare neoplasm. No cases of successful pregnancy and delivery following fertility-sparing management have been reported in the literature.\n\nCase presentation: From September 2020 to January 2026, we identified a 36-year-old nulliparous woman diagnosed with uterine immature teratoma, who achieved successful pregnancy and delivery following standardized fertility-sparing management. The patient presented with a four‑month history of abnormal vaginal bleeding. Pelvic contrast‑enhanced magnetic resonance imaging (MRI) revealed a 9.5 cm × 8.5 cm × 7.5 cm mixed cystic‑solid mass in the lower middle uterine cavity. Tumor marker levels were all within normal limits. The patient underwent two surgical procedures. The first was an incomplete tumor resection; histopathological examination confirmed a grade 2 uterine immature teratoma. The second procedure achieved complete tumor resection, and pathological examination of the resected specimen showed a mature teratoma. Postoperatively, the patient received four cycles of bleomycin, etoposide, and cisplatin (BEP) chemotherapy. One and a half years later, she delivered successfully and has remained recurrence‑free during five years of follow‑up.\n\nConclusions: This case highlights the diagnostic and therapeutic challenges of uterine immature teratoma. For patients desiring fertility preservation, a fertility-sparing approach may be considered when the disease is confined to the endometrium, in the absence of other malignant components, with grade 1–2 histology, and provided that there is a favorable response to chemotherapy.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12884-026-09727-5.",
  "abstract_shown": true,
  "affiliations": [
    "Senior Department of Obstetrics & Gynecology, the Seventh Medical Center of PLA General Hospital, Beijing, China"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaolan Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongxian Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Ke Niu"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenying Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hua Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenjie Shen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e59a54xbwcx56.bib",
  "cited_by": 0,
  "doi": "10.1186/s12884-026-09727-5",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13712094/",
  "id": "e59a54xbwcx56",
  "issns": [
    "1471-2393"
  ],
  "landing_url": "https://doi.org/10.1186/s12884-026-09727-5",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2746|Teratomas and Epidermoid Cysts"
    ]
  ],
  "openalex": "W7171789377",
  "pdf_url": null,
  "pmcid": "PMC13712094",
  "pmid": "42934552",
  "published": "2026-07-30",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/e59a54xbwcx56.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:44Z",
      "native_id": "PMC13712094",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12884-026-09727-5"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Teratomas and Epidermoid Cysts",
      "subfield": "surgery"
    }
  ],
  "title": "Successful delivery after fertility-sparing management for uterine immature teratoma : a case report and literature review",
  "title_text": "Successful delivery after fertility-sparing management for uterine immature teratoma : a case report and literature review",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:44Z",
  "url": "https://research.draconitic.com/paper/e59a54xbwcx56",
  "venue": "BMC Pregnancy and Childbirth",
  "versions": []
}