{
  "abstract": "Radiotherapy is a cornerstone of cancer treatment; however, despite major technological advances, radiation-induced injury to surrounding healthy tissues remains a significant clinical challenge. Here, we developed a preclinical rat model of radiation proctitis using localized, fractionated colorectal irradiation followed by comprehensive histopathological characterization. To enable local drug delivery while minimizing systemic exposure, we engineered a self-rolling bilayer PEG-PLA film loaded with the anti-inflammatory drug prednisolone. The biomaterial was optimized for endoscopic implantation into the irradiated colorectum, providing a minimally invasive therapeutic approach. Local administration of prednisolone significantly reduced the secretion of pro-inflammatory cytokines, including IL-1β, within the colonic mucosa, demonstrating the efficacy of the device in attenuating radiation-induced inflammation. Beyond prednisolone delivery, this adaptable platform could support localized administration of a broad range of therapeutic agents, including biologics or other compounds whose systemic use is limited by toxicity, poor tolerability, or high cost.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Diego Amarante-Silva"
    },
    {
      "name": "Christelle Demarquay"
    },
    {
      "name": "Benjamin Nottelet"
    },
    {
      "name": "Mathilde Grosjean"
    },
    {
      "name": "Sidzigui Ouedraogo"
    },
    {
      "name": "Fabien Milliat"
    },
    {
      "name": "Karine Anselme"
    },
    {
      "name": "Arnaud Ponche"
    },
    {
      "name": "Noëlle Mathieu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e59hf38zf56te.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117453",
  "fulltext_url": null,
  "id": "e59hf38zf56te",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://asnr.hal.science/hal-05769354v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "3003|Advanced Drug Delivery Systems"
    ]
  ],
  "openalex": "W7207714062",
  "pdf_url": "https://asnr.hal.science/hal-05769354/document",
  "pmcid": null,
  "pmid": "42733649",
  "published": "2026-09-03",
  "publisher": "Cell Press, Elsevier [2018-....]",
  "ris": "https://research.draconitic.com/paper/e59hf38zf56te.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "hal-05769354",
      "source": "hal",
      "url": "https://asnr.hal.science/hal-05769354v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Advanced Drug Delivery Systems",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Self-rolling film for in vivo drug delivery to limit colonic inflammation induced after radiation exposure",
  "title_text": "Self-rolling film for in vivo drug delivery to limit colonic inflammation induced after radiation exposure",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/e59hf38zf56te",
  "venue": "iScience",
  "versions": []
}