{
  "abstract": "Bang sensitivity (BS) is a well-characterized seizure-and-paralysis phenotype in Drosophila melanogaster, but its genetic basis remains unexamined in the phylogenetically distant sister species Drosophila funebris. Here, we identify a naturally occurring BS strain in D. funebris from a wild population near Lake Valday, characterized by acute mechanical shock-induced seizures and paralysis, and examine its molecular-genetic and lipidomic basis. Comparative transcriptomics identified 241 differentially expressed genes (FDR-adjusted p < 0.05), with “fatty acid metabolic process” as the most enriched GO term. Notably, within this pathway, the peroxisomal acyl-CoA oxidase gene Acox57D-d showed the most significant downregulation (log2FC = −4.21, padj = 4.1 × 10−110), validated by head-specific RT-qPCR. Untargeted lipidomics of BS heads (LC-Q-TOF-MS) revealed 145 altered lipid species, dominated by oxygenated triacylglycerol accumulation, cardiolipin/phosphatidylethanolamine depletion, and a divergent shift—depletion of DG 29:0 and accumulation of DG 47:4, reflecting impaired peroxisomal β-oxidation and potential mitochondrial and Na+/K+-ATPase dysfunction. These findings nominate Acox57D-d as a leading candidate gene associated with the phenotype and molecular signature of the studied BS line and establish this natural BS strain as a potentially useful model for investigating the relationship between peroxisomal lipid metabolism, neuronal excitability, and insect thanatosis.",
  "abstract_shown": true,
  "affiliations": [
    "Vavilov Institute of General Genetics Russian Academy of Sciences, Gubkin St. 3, 119991 Moscow, Russia",
    "Mental Health Research Center, Clinical Genetics Laboratory, Kashirskoe Sh. 34, 115522 Moscow, Russia",
    "Department of Postgenomics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia",
    "National Research Centre “Kurchatov Institute”, 2 Kurchatov Sq., 123182 Moscow, Russia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Karina A. Kosherova",
      "orcid": "0000-0001-5699-9878"
    },
    {
      "affs": [
        1
      ],
      "name": "Dmitrii A. Abashkin",
      "orcid": "0000-0001-6659-9851"
    },
    {
      "affs": [
        2
      ],
      "name": "Natalya B. Zakharzhevskaya"
    },
    {
      "affs": [
        2
      ],
      "name": "Victoriia D. Kazakova",
      "orcid": "0000-0002-0788-6938"
    },
    {
      "affs": [
        2
      ],
      "name": "Elizaveta A. Vorobyeva"
    },
    {
      "affs": [
        3
      ],
      "name": "Alexander V. Symonenko",
      "orcid": "0000-0003-1473-4470"
    },
    {
      "affs": [
        0
      ],
      "name": "Dmitry V. Mukha",
      "orcid": "0000-0002-7380-0776"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e5axfqwdaqcp7.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198845",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665471/?tool=EBI",
  "id": "e5axfqwdaqcp7",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13665471",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2804|Neurobiology and Insect Physiology Research"
    ]
  ],
  "openalex": "W7220362851",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665471/pdf/?tool=EBI",
  "pmcid": "PMC13665471",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/e5axfqwdaqcp7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "PMC:PMC13665471",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13665471"
    },
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27198845",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/19/8845"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Neurobiology and Insect Physiology Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "The First Report of a Bang-Sensitive Strain in Drosophila funebris: Molecular-Genetic and Lipidomic Characterization",
  "title_text": "The First Report of a Bang-Sensitive Strain in Drosophila funebris: Molecular-Genetic and Lipidomic Characterization",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:55Z",
  "url": "https://research.draconitic.com/paper/e5axfqwdaqcp7",
  "venue": "International journal of molecular sciences",
  "versions": []
}