{
  "abstract": "Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogens affecting the global swine industry. This review summarizes current knowledge of PRRSV-induced suppression of adaptive immune responses, with particular emphasis on impaired T cell activity, dysregulated B cell responses, delayed and insufficient neutralizing antibody production, and viral strategies that limit effective immune clearance. In addition, recent advances and limitations in vaccine development and antiviral strategies are presented. By integrating insights from viral pathogenesis and host immune responses, this review provides a comprehensive perspective on current challenges and emerging strategies for effective PRRSV control.",
  "abstract_shown": true,
  "affiliations": [
    "School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.",
    "State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.",
    "Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou 730046, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ning Zhu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jincheng Zhong"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Zengjun Lu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jing Zhang",
      "orcid": "0000-0002-4965-7076"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e5cr6k8gqak0m.bib",
  "cited_by": 0,
  "doi": "10.3390/v18101077",
  "fulltext_url": "https://europepmc.org/articles/PMC13709390",
  "id": "e5cr6k8gqak0m",
  "issns": [
    "1999-4915"
  ],
  "landing_url": "https://europepmc.org/article/MED/42943997",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QR1-502"
    ],
    [
      "openalex",
      "1103|Animal Virus Infections Studies"
    ]
  ],
  "openalex": "W7214707563",
  "pdf_url": "https://europepmc.org/articles/PMC13709390?pdf=render",
  "pmcid": "PMC13709390",
  "pmid": "42943997",
  "published": "2026-09-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/e5cr6k8gqak0m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42943997",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42943997"
    },
    {
      "first_seen": "2026-10-31T14:21:37Z",
      "native_id": "0ec3ef3af8b74367b4563ce4800be6a6",
      "source": "doaj",
      "url": "https://doi.org/10.3390/v18101077"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1103|Animal Virus Infections Studies",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Porcine Reproductive and Respiratory Syndrome Virus: Adaptive Immunity, Immune Evasion and Emerging Strategies for Disease Control.",
  "title_text": "Porcine Reproductive and Respiratory Syndrome Virus: Adaptive Immunity, Immune Evasion and Emerging Strategies for Disease Control.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:21:37Z",
  "url": "https://research.draconitic.com/paper/e5cr6k8gqak0m",
  "venue": "Viruses",
  "versions": []
}