{
  "abstract": "Citrus flavonoids have various health-promoting effects, such as antioxidant, anti-inflammatory, and metabolic regulatory activities, whereas their low oral bioavailability greatly impairs their in vivo efficacy. Substitution patterns of hydroxyl, methoxyl, and glycosyl groups determine their metabolic fate. As a narrative review, this paper follows the thread of “structure-metabolism-efficacy” and reviews literature covering metabolism, gut microbiota, delivery systems, structural modifications, in vivo bioactivity, and clinical studies. Molecular-structure-based comparisons of bioavailability-enhancement strategies are made. Most bioactivity findings are derived from cellular and animal studies, while human pharmacokinetic and clinical data remain scarce. Prospects, including AI-assisted formulation, personalized nutrition, and high-value utilization of citrus by-products, are discussed, aiming to provide an in-depth theoretical reference for the development of citrus-flavonoid-based functional products.",
  "abstract_shown": true,
  "affiliations": [
    "College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China",
    "College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China; Corresponding authors at: National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.",
    "College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China; Shandong Haizhibao Ocean Science and Technology Co., Ltd., Rongcheng 264300, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jingjing Geng"
    },
    {
      "affs": [
        1
      ],
      "name": "Jing Deng"
    },
    {
      "name": "Wenhu Zhou"
    },
    {
      "affs": [
        1
      ],
      "name": "Wen Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jintao He"
    },
    {
      "affs": [
        2
      ],
      "name": "Qinlu Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Jie Bai"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingming Cao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e5hef1ct0cbm9.bib",
  "cited_by": 1,
  "doi": "10.1016/j.fochx.2026.104433",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2590157526009545",
  "id": "e5hef1ct0cbm9",
  "issns": [
    "2590-1575"
  ],
  "landing_url": "https://doi.org/10.1016/j.fochx.2026.104433",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "TP368-456"
    ],
    [
      "lcc",
      "TX341-641"
    ],
    [
      "openalex",
      "2704|Phytochemicals and Antioxidant Activities"
    ]
  ],
  "openalex": "W7212049871",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2590157526009545/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/e5hef1ct0cbm9.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:22:02Z",
      "native_id": "0504bf206ddf4b1888d895a38d7ae7eb",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.fochx.2026.104433"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:TX341-641",
      "subfield": "nutrition"
    }
  ],
  "title": "Research progress on the metabolic fate of citrus flavonoids and strategies to improve bioavailability",
  "title_text": "Research progress on the metabolic fate of citrus flavonoids and strategies to improve bioavailability",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:02Z",
  "url": "https://research.draconitic.com/paper/e5hef1ct0cbm9",
  "venue": "Food Chemistry: X",
  "versions": []
}