{
  "abstract": "An enantioselective NHC-catalyzed strategy for the synthesis of spirocyclic carbazole derivatives was developed through oxidative remote N–H activation of readily available 1-formylcarbazoles. Catalytic generation of aza-ortho-quinone methides enables efficient annulation with thioisatins, underexplored electrophiles in asymmetric NHC catalysis. The protocol is also compatible with conventional isatins, affording structurally diverse spirocyclic heteroaromatic products in acceptable to good yields (up to 76%) and enantiomeric ratios up to 98:2 er. The utility of the method was demonstrated on gram-scale, while successful coupling with an acyclic ketone further illustrates the broader synthetic potential of this remote N–H activation process.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 2030/8, Prague, Czech Republic, 128 00",
    "Department of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030/8, Prague, Czech Republic, 128 00"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ladislav Lóška",
      "orcid": "0009-0001-8755-3112"
    },
    {
      "affs": [
        1
      ],
      "name": "Ivana Císařová",
      "orcid": "0000-0002-9612-9831"
    },
    {
      "affs": [
        0
      ],
      "name": "Jan Veselý",
      "orcid": "0000-0001-5198-8950"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e5neargchsh2m.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009225/v1",
  "fulltext_url": null,
  "id": "e5neargchsh2m",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009225/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|N-Heterocyclic Carbenes in Organic and Inorganic Chemistry"
    ]
  ],
  "openalex": "W7213971106",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009225/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-22",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/e5neargchsh2m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009225",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009225/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|N-Heterocyclic Carbenes in Organic and Inorganic Chemistry",
      "subfield": "organic"
    }
  ],
  "title": "Enantioselective Synthesis of Carbazole-Thioisatin Spirocycles via NHC-Catalyzed Remote N–H Activation",
  "title_text": "Enantioselective Synthesis of Carbazole-Thioisatin Spirocycles via NHC-Catalyzed Remote N–H Activation",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/e5neargchsh2m",
  "venue": "ChemRxiv",
  "versions": []
}