{
  "abstract": "Multiple sclerosis (MS) is a complex immune-mediated disorder with polygenic and multicellular underpinnings, necessitating cell-type-specific molecular studies to delineate dysregulated pathways. Here, we profile 1,075 transcriptomes from 167 patients with MS and 42 healthy participants across six peripheral immune cell-type-states. MS-associated transcriptional differences are more pronounced in primary (unstimulated) immune cells than in in vitro-stimulated counterparts. We identify shared and cell-type-specific transcriptional alterations at the level of genes, pathways, and co-expressed gene modules, prioritizing regulators, such as ZBTB16, across T cells and monocytes, and replicating six MS-associated modules in independent datasets. The top T cell module is enriched for MS susceptibility genes and affects proliferation. The top monocyte module implicates dysregulated TNF-α/NF-κB signaling, for which an in silico drug screen and in vitro validation nominate alvespimycin as a candidate modulator. Together, these findings define stable peripheral immune dysregulation signatures in MS that may serve as diagnostic or prognostic biomarkers in at-risk individuals.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 26,
  "authors": [
    {
      "name": "Tina Roostaei"
    },
    {
      "name": "Masashi Fujita"
    },
    {
      "name": "Hanane Touil"
    },
    {
      "name": "Pia Kivisäkk"
    },
    {
      "name": "Cristin Mccabe"
    },
    {
      "name": "Parham Nejad"
    },
    {
      "name": "Afsana Sabrin"
    },
    {
      "name": "Frankie Garcia"
    },
    {
      "name": "Christiaan van Dorp"
    },
    {
      "name": "Daniel Felsky"
    },
    {
      "name": "Ioannis Vlachos"
    },
    {
      "name": "Daniel Hui"
    },
    {
      "name": "Jennifer Fransson"
    },
    {
      "name": "Will Macnair"
    },
    {
      "name": "Anna Williams"
    },
    {
      "name": "Lili Zhang"
    },
    {
      "name": "Wen Zhu"
    },
    {
      "name": "Zongqi Xia"
    },
    {
      "name": "Violetta Zujovic"
    },
    {
      "name": "Nikolaos Patsopoulos"
    },
    {
      "name": "Andrew Yates"
    },
    {
      "name": "Vijay Kuchroo"
    },
    {
      "name": "Tanuja Chitnis"
    },
    {
      "name": "Howard Weiner"
    },
    {
      "name": "Hans-Ulrich Klein"
    },
    {
      "name": "Philip de Jager"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e5nehgxvn01p5.bib",
  "cited_by": 1,
  "doi": "10.1016/j.celrep.2026.117417",
  "fulltext_url": null,
  "id": "e5nehgxvn01p5",
  "issns": [
    "2211-1247",
    "2211-1247"
  ],
  "landing_url": "https://hal.science/hal-05772384v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2734|Multiple Sclerosis Research Studies"
    ]
  ],
  "openalex": "W7163677732",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Elsevier Inc",
  "ris": "https://research.draconitic.com/paper/e5nehgxvn01p5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:44Z",
      "native_id": "hal-05772384",
      "source": "hal",
      "url": "https://hal.science/hal-05772384v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis",
  "title_text": "Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:44Z",
  "url": "https://research.draconitic.com/paper/e5nehgxvn01p5",
  "venue": "Cell Reports",
  "versions": []
}