{
  "abstract": "Introduction To compare long-term effectiveness and obstetric outcomes of focused ultrasound (FU) ablation versus loop electrosurgical excision procedure (LEEP) for high-grade squamous intraepithelial lesions (HSIL) in reproductive-aged women.Materials and methods This retrospective cohort included women treated with FU (n = 29) or LEEP (n = 32) for HSIL who subsequently delivered (2017–2023). A control group (n = 61) comprised healthy women with negative preconception HR-HPV/cytology. Outcomes were cumulative HR-HPV clearance, cervical length, pregnancy outcomes.Results Both FU and LEEP demonstrated comparable long-term effectiveness: cumulative HR-HPV clearance rates did not differ significantly at any time point (p > 0.05). Post-intervention cervical length was significantly shorter in the LEEP group (24.79 ± 3.98 mm) than in both the FU (27.63 ± 2.80 mm) and control (28.26 ± 3.92 mm) groups (p = 0.003). Cervical insufficiency was more frequent in the LEEP group (15.63%) than in the FU (3.45%) and control (1.64%) groups (p = 0.019). The LEEP group also had higher rates of preterm birth (18.75% vs 3.45% in FU and 4.92% in controls; p = 0.039) and lower rates of vaginal delivery (15.63% vs 44.83% in FU; p = 0.025).Conclusion In this selected cohort of women with successful live births, FU may have comparable long-term effectiveness to LEEP for HSIL while potentially preserving cervical length and reducing adverse obstetric risks. These preliminary findings suggest FU may be a fertility-sparing option for appropriately selected HSIL women who are planning pregnancy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gynecology and Obstetrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China",
    "North Sichuan Medical College, Nanchong, China",
    "State Key Laboratory of Ultrasound in Medicine and Engineering College of Biomedical Engineering, Chongqing Medical University, Chongqing, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
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        0
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      "name": "Miao Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Fei Long"
    },
    {
      "affs": [
        0
      ],
      "name": "Yujuan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiao Jing"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaojiao Ren"
    },
    {
      "affs": [
        0
      ],
      "name": "Liming Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Chenzhi Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Qiuling Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Honggui Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e5rr57hmq308t.bib",
  "cited_by": 0,
  "doi": "10.1080/02656736.2026.2749296",
  "fulltext_url": "https://www.tandfonline.com/doi/10.1080/02656736.2026.2749296",
  "id": "e5rr57hmq308t",
  "issns": [
    "1464-5157",
    "0265-6736"
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  "landing_url": "https://doi.org/10.1080/02656736.2026.2749296",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
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      "lcc",
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      "openalex",
      "2713|Cervical Cancer and HPV Research"
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  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/02656736.2026.2749296?needAccess=true",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "Taylor & Francis Group",
  "ris": "https://research.draconitic.com/paper/e5rr57hmq308t.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:22:03Z",
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  "subjects": [
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      "field": "medicine",
      "origin": "openalex:2713|Cervical Cancer and HPV Research",
      "subfield": "epidemiology-public-health"
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  "title": "Focused ultrasound versus LEEP for high-grade squamous intraepithelial lesions: a retrospective cohort study of long-term effectiveness and obstetric outcomes",
  "title_text": "Focused ultrasound versus LEEP for high-grade squamous intraepithelial lesions: a retrospective cohort study of long-term effectiveness and obstetric outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:03Z",
  "url": "https://research.draconitic.com/paper/e5rr57hmq308t",
  "venue": "International Journal of Hyperthermia",
  "versions": []
}