{
  "abstract": "The diagnosis of first-episode psychosis (FEP) in adolescents and young adults remains primarily clinical, often complicated by symptom overlap and the heterogeneity of psychiatric presentations. There is a critical need for non-invasive, objective biomarkers to support early diagnosis and patient stratification. This study aimed to replicate a panel of 10 candidate microRNAs (miRNAs) identified in a previous exploratory study within a larger, independent cohort of treatment-naïve Romanian adolescents and young adults. This cross-sectional study included 50 participants (22 drug-naïve FEP patients and 28 age- and sex-matched controls). Total RNA was isolated from plasma, and the levels of miRNAs were measured using qRT-PCR. Clinical symptoms were assessed using standardized psychiatric scales (PANSS, HDRS, YMRS). We successfully replicated miR-1260a as significantly modified in the plasma of treatment-naïve FEP patients compared to controls (FDR Adj. p = 0.04). ROC analysis for miR-1260a yielded an AUC of 0.741 (p = 0.004). Furthermore, exploratory correlation analyses conducted exclusively within the FEP patient group indicated a negative correlation between miR-1260a levels and the positive PANSS score (p = 0.017, rho = -0.503), which did not retain statistical significance after FDR correction (FDR Adj. p = 0.102). Our results corroborate and enhance our prior exploratory research, highlighting miR-1260a as a prominent candidate among circulating biomarkers for early psychosis. Future longitudinal studies are necessary to evaluate the diagnostic, prognostic, and clinical monitoring efficacy of this miRNA.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medicine, Carol Davila University of Medicine and Pharmacy , ,",
    "Victor Babes, National Institute of Pathology , ,",
    "Aproape Clinic , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ștefania-Alexandra Grosu"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Dobre"
    },
    {
      "affs": [
        1
      ],
      "name": "Iulia Andreea Pelisenco"
    },
    {
      "affs": [
        2
      ],
      "name": "Radu-Mihai Paun"
    },
    {
      "affs": [
        0
      ],
      "name": "Elena Milanesi"
    },
    {
      "affs": [
        0
      ],
      "name": "Mihail Eugen Hinescu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e5tvbeqkszf6j.bib",
  "cited_by": 0,
  "doi": "10.3389/fpsyt.2026.1947759",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672503/?tool=EBI",
  "id": "e5tvbeqkszf6j",
  "issns": [
    "1664-0640"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13672503",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Schizophrenia research and treatment"
    ]
  ],
  "openalex": "W7216028731",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672503/pdf/?tool=EBI",
  "pmcid": "PMC13672503",
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/e5tvbeqkszf6j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13672503",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13672503"
    },
    {
      "first_seen": "2026-10-30T12:20:18Z",
      "native_id": "10.3389/fpsyt.2026.1947759",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1947759/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Schizophrenia research and treatment",
      "subfield": "psychiatry"
    }
  ],
  "title": "Circulating miR-1260a as a potential biomarker for First-Episode of Psychosis: a replication study in a treatment-Naïve Romanian cohort",
  "title_text": "Circulating miR-1260a as a potential biomarker for First-Episode of Psychosis: a replication study in a treatment-Naïve Romanian cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:18Z",
  "url": "https://research.draconitic.com/paper/e5tvbeqkszf6j",
  "venue": "Frontiers in psychiatry",
  "versions": []
}