{
  "abstract": "H3K27ac epigenetically modulates gene expression and serves as an indicator of cancer status. Although aberrant H3K27ac has been widely studied, a comprehensive landscape of cancer-specific H3K27ac patterns remains lacking. By integrating 209 H3K27ac ChIP-seq datasets across 48 tissues and cell types, we defined 3612 universally conserved regions and a vast repertoire of cancer-specific H3K27ac alterations. Strikingly, while cancer-specific H3K27ac gains were pervasive across leukemia, hepatocellular carcinoma, breast cancer, lung adenocarcinoma, and lymphoma, losses were remarkably rare. These cancer-specific H3K27ac gains were predominantly enriched in non-coding regions, where they were associated with increased chromatin accessibility and chromatin interactions, enabling the recruitment of oncogenic transcription factors to activate target genes. Conversely, cancer-specific H3K27ac losses preferentially occurred in promoters and correlated with chromatin compaction and transcriptional repression. Mechanistic multi-omics analyses in leukemia further demonstrated this epigenetic-structural coupling. Leukemia-specific H3K27ac gains established a permissive chromatin environment that facilitated oncogenic GATA1 binding and activation of its target gene TAL1. Within this context, TAL1 exhibited increased interaction with STIL, a well-known fusion partner implicated in leukemogenesis. To enable broader application of these findings, we developed an open-access web server for genomic annotation. Collectively, our study provides a comprehensive landscape of cancer-specific H3K27ac modifications, defining them as a functional epigenetic signature of oncogenic chromatin remodeling and offering an annotation resource for understanding the regulation of the cancer genome.",
  "abstract_shown": true,
  "affiliations": [
    "Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China",
    "Inner Mongolia Traditional Chinese & Mongolian Medical Research Institute, Hohhot 010020, China",
    "School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yu-Shuo Zhuang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuan-Yuan Gao"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhao-Yue Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhe-Peng Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jun-Jie Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Li-Rong Zhang",
      "orcid": "0000-0001-5366-4837"
    },
    {
      "affs": [
        1
      ],
      "name": "Siqin Bateer"
    },
    {
      "affs": [
        0
      ],
      "name": "Lu-Qiang Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e5xj95erg0dan.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219606",
  "fulltext_url": null,
  "id": "e5xj95erg0dan",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9606",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Genomics and Chromatin Dynamics"
    ]
  ],
  "openalex": "W7223969463",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/e5xj95erg0dan.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27219606",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9606"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Genomics and Chromatin Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Deciphering Cancer-Specific H3K27ac Landscapes Through Systematic Multi-Omics Integration and Development of Open-Access Genomic Annotation Platform",
  "title_text": "Deciphering Cancer-Specific H3K27ac Landscapes Through Systematic Multi-Omics Integration and Development of Open-Access Genomic Annotation Platform",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:57Z",
  "url": "https://research.draconitic.com/paper/e5xj95erg0dan",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}