{
  "abstract": "Metagenomic studies of arthropod-associated microbiomes have generated vast amounts of sequence data, yet the functional and structural organization of these proteins remains largely unexplored. Here, we present ArthroVerse, the first comprehensive database of protein families derived from arthropod-associated metagenomes. Non-redundant protein families were generated after rigorous filtering, deduplication, and clustering. The protein families were further annotated with microbial taxonomy, host associations, protein structural information, and carbohydrate-active enzymes predictions. The resulting dataset integrates both metagenomic and reference genome-derived proteins, enabling systematic exploration of functional diversity, evolutionary relationships, and host-microbe interactions in insect microbiomes. ArthroVerse provides a valuable resource for the study of microbial ecology and arthropod physiology, offering unprecedented insight into the protein landscape of insect-associated microbial communities. ArthroVerse is publicly accessible at https://envofams.org/arthroverse/.",
  "abstract_shown": true,
  "affiliations": [
    "Institute for Fundamental Biomedical Research, BSRC “Alexander Fleming”, Vari 16672 ,",
    "Department of Informatics and Telecommunications, National and Kapodistrian University of Athens , Athens 16122 ,",
    "Division of Basic Sciences, University of Crete Medical School , 71110 Heraklion ,",
    "Medical School of Athens, National and Kapodistrian University of Athens , Goudi 11527 ,",
    "Athena Research Center , Marousi 15125 ,",
    "Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute , 1400 Barbara Jordan Blvd., Austin, TX 78723 ,",
    "Observatory of biodiversity dynamics, QUYFIN , Athens 17562 ,",
    "Section of Cell Biology and Biophysics, Department of Biology, School of Science, National and Kapodistrian University of Athens (NKUA) , Athens 15701 ,",
    "European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridge CB10 1SD ,",
    "DOE Joint Genome Institute, Lawrence Berkeley National Laboratory , 1 Cyclotron Road, Berkeley, CA 94720 ,",
    "Division of Biological and Life Sciences, Mohamed bin Zayed University of Artificial Intelligence (MBZUAI) , Building 1B, Masdar City, Abu Dhabi SE45 05 ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Iro N Chasapi"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Eleni Aplakidou",
      "orcid": "0009-0002-0737-4817"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Maria N Chasapi",
      "orcid": "0009-0009-0336-0515"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Efthimia Lamari"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandros Galaras"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Sophia Diplari"
    },
    {
      "affs": [
        2
      ],
      "name": "Ioannis Iliopoulos",
      "orcid": "0000-0002-9079-0565"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Ioannis Z Emiris"
    },
    {
      "affs": [
        5
      ],
      "name": "Ilias Georgakopoulos-Soares"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Solenn Patalano"
    },
    {
      "affs": [
        7
      ],
      "name": "Dimitrios J Stravopodis"
    },
    {
      "affs": [
        8
      ],
      "name": "Evangelos Karatzas",
      "orcid": "0000-0001-9132-8981"
    },
    {
      "affs": [
        0
      ],
      "name": "Fotis A Baltoumas",
      "orcid": "0000-0002-2870-2931"
    },
    {
      "affs": [
        9
      ],
      "name": "Nikos C Kyrpides",
      "orcid": "0000-0002-6131-0462"
    },
    {
      "affs": [
        0,
        10
      ],
      "name": "Georgios A Pavlopoulos",
      "orcid": "0000-0002-4577-8276"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e5y1qjte52404.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag1067",
  "fulltext_url": null,
  "id": "e5y1qjte52404",
  "issns": [
    "0305-1048",
    "1362-4962"
  ],
  "landing_url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1067/9002503",
  "language": null,
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1109|Insect symbiosis and bacterial influences"
    ]
  ],
  "openalex": "W7168101341",
  "pdf_url": "https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkag1067/72528729/gkag1067.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/e5y1qjte52404.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:50Z",
      "native_id": "10.1093/nar/gkag1067",
      "source": "crossref",
      "url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1067/9002503"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1109|Insect symbiosis and bacterial influences",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "ArthroVerse: mapping protein family diversity across arthropod-associated microbiomes",
  "title_text": "ArthroVerse: mapping protein family diversity across arthropod-associated microbiomes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:50Z",
  "url": "https://research.draconitic.com/paper/e5y1qjte52404",
  "venue": "Nucleic Acids Research",
  "versions": []
}