{
  "abstract": "An encrusting, algae-associated octocoral, Briareum stechei, afforded three 8,17-epoxybriarane diterpenoids, including the known compound briaexcavatolide B (1) and two previously undescribed analogues, briastecholides Q (2) and R (3). The absolute configuration of 1 was established for the first time by single-crystal X-ray diffraction analysis. The planar structures and relative configurations of 2 and 3 were determined through extensive spectroscopic analyses. In bioactivity evaluation, compound 2 exhibited cytotoxic effects toward the human acute lymphoblastic leukemia cell lines Molt-4 and CCRF-CEM.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Yuan-Hao Liu"
    },
    {
      "name": "Chih-Kai Hsu"
    },
    {
      "name": "Liu-Guo Zheng"
    },
    {
      "name": "Su-Ying Chien"
    },
    {
      "name": "Yu-Jen Wu"
    },
    {
      "name": "Jih-Jung Chen"
    },
    {
      "name": "Mingzi M. Zhang"
    },
    {
      "name": "Zhi-Hong Wen"
    },
    {
      "name": "Yuan-Bin Cheng"
    },
    {
      "name": "Lun Kelvin Tsou"
    },
    {
      "name": "Mei-Chin Lu"
    },
    {
      "name": "Jyh-Horng Sheu"
    },
    {
      "name": "Shih-Hsiung Lin"
    },
    {
      "name": "Ping-Jyun Sung"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e6275z2w5mget.bib",
  "cited_by": 0,
  "doi": "10.1248/cpb.c26-00274",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00274/_article",
  "id": "e6275z2w5mget",
  "issns": [
    "1347-5223",
    "0009-2363"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00274/_article",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "chemistry/medicinal"
    ],
    [
      "openalex",
      "1312|Bioactive Natural Diterpenoids Research"
    ]
  ],
  "openalex": "W7172290265",
  "pdf_url": "https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00274/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e6275z2w5mget.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "10.1248/cpb.c26-00274",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00274/_article"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bioactive Natural Diterpenoids Research",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei",
  "title_text": "Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/e6275z2w5mget",
  "venue": "Chemical and Pharmaceutical Bulletin",
  "versions": []
}