{
  "abstract": "Hyperpigmentation disorders motivate the search for structurally defined and effective natural depigmenting agents from plant-derived polysaccharides. The present study characterized the structural features and evaluated the anti-melanogenic activity of ACP-II-1, a novel pectic polysaccharide isolated from Alhagi camelorum Fisch. ACP-II-1 had a molecular weight of 26.145 kDa and contained GalA, Rha, Gal, Ara, GlcA, and Xyl at respective molar proportions of 0.798, 0.072, 0.053, 0.052, 0.016, and 0.009. Integrated monosaccharide, methylation, FT-IR, and NMR analyses indicated a GalA-rich structure dominated by homogalacturonan (HG)-type →4)-α-D-GalpA-(1→ sequences, with less abundant branched rhamnogalacturonan-I (RG-I)-type motifs and heterogeneous neutral side-chain motifs. In forskolin-stimulated B16F10 cells, ACP-II-1 significantly lowered melanin content and cellular tyrosinase activity; it also decreased pigmentation and tyrosinase activity in zebrafish. These effects in B16F10 cells coincided with lower MITF, TYR, TRP-1, and TRP-2 protein levels, together with altered readouts associated with GSK-3β/β-catenin, PKA/CREB, and p38/JNK signaling. Collectively, these findings support the anti-melanogenic potential of ACP-II-1 and warrant further validation in mammalian and human-relevant skin models, together with comprehensive safety evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.",
    "University of Chinese Academy of Sciences, Beijing, China.",
    "Qinghai Normal University, Xining, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Zhitao Liu",
      "orcid": "0009-0007-3945-2863"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shuyan Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Nannan Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Nuermaimaiti Abudukelimu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiangyu Zhao",
      "orcid": "0009-0004-1122-7048"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e69qjbz5hmbgq.bib",
  "cited_by": 0,
  "doi": "10.1002/cbdv.71878",
  "fulltext_url": "https://europepmc.org/articles/PMC13720961",
  "id": "e69qjbz5hmbgq",
  "issns": [
    "1612-1872",
    "1612-1880"
  ],
  "landing_url": "https://europepmc.org/article/MED/42960694",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1110|Polysaccharides and Plant Cell Walls"
    ]
  ],
  "openalex": "W7224886142",
  "pdf_url": "https://europepmc.org/articles/PMC13720961?pdf=render",
  "pmcid": "PMC13720961",
  "pmid": "42960694",
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e69qjbz5hmbgq.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42960694",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960694"
    },
    {
      "first_seen": "2026-11-03T12:21:44Z",
      "native_id": "PMC13720961",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cbdv.71878"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Polysaccharides and Plant Cell Walls",
      "subfield": "plant-biology"
    }
  ],
  "title": "Isolation, Structural Elucidation, and Anti-Melanogenic Activity of a Novel Pectic Polysaccharide From Alhagi camelorum Fisch.",
  "title_text": "Isolation, Structural Elucidation, and Anti-Melanogenic Activity of a Novel Pectic Polysaccharide From Alhagi camelorum Fisch.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:44Z",
  "url": "https://research.draconitic.com/paper/e69qjbz5hmbgq",
  "venue": "Chemistry & biodiversity",
  "versions": []
}