{
  "abstract": "Ribosome heterogeneity can regulate translation, but how changes in ribosome chemistry reshape cellular programs and contribute to diseases such as cancer remains incompletely understood. Here we show that SNORA81-guided pseudouridylation at a single 28S ribosomal RNA site, U4636, links ribosome heterogeneity to selective translation and ovarian cancer cell proliferation. This partially modified site contacts eL31 near the peptide-exit region. SNORA81 depletion reduces U4636 pseudouridylation and changes ribosome occupancy in relation to codon identity and nascent-peptide properties without broadly disrupting rRNA processing or bulk polysome profiles. Depletion also redistributes mRNAs with distinct GC content and amino-acid composition across polysomes, with corresponding protein-abundance changes in selected cancer-associated targets. Wild-type SNORA81, but not a guide-region mutant, restores proliferation. Together, these findings support a \"sno-balling\" model in which altered abundance of a single snoRNA propagates through rRNA modification, selective ribosome engagement and protein output to reshape cancer-associated gene expression and cell behavior.",
  "abstract_shown": true,
  "affiliations": [
    "Universite de Sherbrooke"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "L. Faucher-Giguere"
    },
    {
      "name": "A. Rivera-Pizana"
    },
    {
      "name": "B. Seguineau de Preval"
    },
    {
      "name": "E. Fafard-Couture"
    },
    {
      "name": "G. Deschamps-Francoeur"
    },
    {
      "name": "V. Marchand"
    },
    {
      "name": "Y. Motorin"
    },
    {
      "name": "C. Barchet"
    },
    {
      "name": "B. P. Klaholz"
    },
    {
      "name": "T. Azad"
    },
    {
      "name": "M. S. Scott"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Abou Elela"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e6egr27cwcbz8.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.06.757013",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.06.757013v1.full",
  "id": "e6egr27cwcbz8",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.06.757013v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cancer biology"
    ],
    [
      "openalex",
      "1312|RNA modifications and cancer"
    ]
  ],
  "openalex": "W7206188513",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.06.757013v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e6egr27cwcbz8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:22Z",
      "native_id": "10.64898/2026.10.06.757013",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.06.757013v2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:cancer biology",
      "subfield": "oncology"
    }
  ],
  "title": "A ribosomal pseudouridine drives an oncogenic translation program",
  "title_text": "A ribosomal pseudouridine drives an oncogenic translation program",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:12Z",
  "url": "https://research.draconitic.com/paper/e6egr27cwcbz8",
  "venue": "bioRxiv",
  "versions": []
}