{
  "abstract": "Derived from the rhizome of Curcuma longa L., curcumin has evolved from a traditional component of South Asian medicine into a prominent topic in modern pharmacology. Curcumin has a pleiotropic pharmacological profile with biological properties including antioxidant, anti-inflammatory, and anticancer effects. However, its clinical translation faces physiological and chemical challenges, characterized by low systemic bioavailability, instability at neutral to alkaline pH, and rapid metabolic clearance. This review examines the molecular mechanisms and biological barriers that limit its efficiency and explores nanotechnology as a strategy to optimize its pharmacokinetic profile. It focuses on nanostructured systems, emphasizing nanoemulsions, to improve stability and prolong systemic circulation. Finally, the current landscape of clinical studies and the prospects for using these nanosystems to manage inflammatory and oncological diseases are discussed to establish curcumin as a therapeutic alternative.",
  "abstract_shown": true,
  "affiliations": [
    "Chimie Interactions Plasma-Surface (ChIPS), Research Institute for Materials Science and Engineering, University of Mons, Av. Nicolas Copernic 3, 7000 Mons, Belgium",
    "Applied Nanostructured Systems Laboratory, Universidade Estadual do Centro-Oeste, UNICENTRO, Alameda Elio Antonio Dalla Vecchia, 838, 85040-167, Guarapuava, PR, Brazil",
    "Department of Food Science, Aarhus University, Agro Food Park 48, 8200 Aarhus, Denmark",
    "School of Medicine and Pharmacy, Biologie humaine et Toxicologie, University of Mons, Avenue du Champ de Mars, 7000 Mons, Belgium"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Daniele De Campos"
    },
    {
      "affs": [
        1
      ],
      "name": "Marciane Zornita Bortolanza"
    },
    {
      "affs": [
        2
      ],
      "name": "Mohamed Fathi Abdallah",
      "orcid": "0000-0002-3903-6452"
    },
    {
      "affs": [
        3
      ],
      "name": "Jean-Marie Colet"
    },
    {
      "affs": [
        0
      ],
      "name": "Julia de Oliveira Primo"
    },
    {
      "affs": [
        0
      ],
      "name": "Carla Bittencourt",
      "orcid": "0000-0002-3330-6693"
    },
    {
      "affs": [
        1
      ],
      "name": "Najeh Maissar Khalil",
      "orcid": "0000-0002-5140-9944"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e6f2vwr29hfkm.bib",
  "cited_by": 0,
  "doi": "10.3762/bjnano.17.102",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725486/",
  "id": "e6f2vwr29hfkm",
  "issns": [
    "2190-4286"
  ],
  "landing_url": "https://doi.org/10.3762/bjnano.17.102",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Nanoscience"
    ],
    [
      "heading",
      "Nanotechnology"
    ],
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1313|Curcumin's Biomedical Applications"
    ]
  ],
  "openalex": "W7224335236",
  "pdf_url": "https://europepmc.org/articles/PMC13725486?pdf=render",
  "pmcid": "PMC13725486",
  "pmid": "42974146",
  "published": "2026-10-29",
  "publisher": "Beilstein-Institut",
  "ris": "https://research.draconitic.com/paper/e6f2vwr29hfkm.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:52Z",
      "native_id": "PMC13725486",
      "source": "pmc",
      "url": "https://doi.org/10.3762/bjnano.17.102"
    },
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974146",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974146"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Curcumin's Biomedical Applications",
      "subfield": "general"
    }
  ],
  "title": "Curcumin pharmacology and pharmacokinetics: current challenges and future perspectives in nanoemulsion delivery",
  "title_text": "Curcumin pharmacology and pharmacokinetics: current challenges and future perspectives in nanoemulsion delivery",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:44Z",
  "url": "https://research.draconitic.com/paper/e6f2vwr29hfkm",
  "venue": "Beilstein Journal of Nanotechnology",
  "versions": []
}