{
  "abstract": "IntroductionDuring the first year of life, the gut microbiota (GM) is influenced by several factors, including delivery mode, feeding practices (breast milk vs. formula milk), antibiotic therapy, and preterm birth. Surgical interventions and complex congenital conditions may further alter microbial colonization, potentially contributing to complications and systemic inflammation. This study aimed to investigate alterations in the GM of newborns with complex surgical, urological, and gastrointestinal conditions, including Hirschsprung's disease.MethodsGM composition was analyzed in five newborns with complex clinical conditions to investigate potential associations between microbial alterations and underlying diseases.ResultsA consistent reduction in beneficial commensal bacteria, particularly Bifidobacterium and Lactobacillus spp., was observed, alongside an increased abundance of potential opportunistic pathogens, mainly belonging to the phylum Proteobacteria. These findings revealed common signatures of dysbiosis, as well as potential disease-specific microbial patterns.DiscussionThe findings suggest that early-life factors, including antibiotic exposure, prematurity, complex clinical conditions, and surgical interventions, may substantially affect microbial colonization. These alterations may be associated with an increased risk of complications and systemic inflammation. Further studies involving larger cohorts are needed to clarify the relationships between GM alterations and clinical outcomes in these vulnerable newborns.",
  "abstract_shown": true,
  "affiliations": [
    "Unit of Microbiome, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy",
    "Neonatal Intensive Care Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy",
    "Unit of Microbiomics, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy",
    "Neonatal and Pediatric Surgery Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy",
    "Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Marsiglia Riccardo"
    },
    {
      "affs": [
        1
      ],
      "name": "Domenico Umberto De Rose"
    },
    {
      "affs": [
        2
      ],
      "name": "Pane Stefania"
    },
    {
      "affs": [
        0
      ],
      "name": "Chiara Marangelo"
    },
    {
      "affs": [
        1
      ],
      "name": "Guglielmo Salvatori"
    },
    {
      "affs": [
        3
      ],
      "name": "Fabio Fusaro"
    },
    {
      "affs": [
        3
      ],
      "name": "Andrea Conforti"
    },
    {
      "affs": [
        1
      ],
      "name": "Irma Capolupo"
    },
    {
      "affs": [
        0
      ],
      "name": "Lorenza Putignani"
    },
    {
      "affs": [
        2
      ],
      "name": "Lorenza Putignani"
    },
    {
      "affs": [
        4
      ],
      "name": "Lorenza Putignani"
    },
    {
      "affs": [
        2
      ],
      "name": "Andrea Dotta"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e6jkz3cc12gq9.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1917675",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fmed.2026.1917675/full",
  "id": "e6jkz3cc12gq9",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://doi.org/10.3389/fmed.2026.1917675",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
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  ],
  "openalex": "W7223331528",
  "pdf_url": "https://europepmc.org/articles/PMC13739509?pdf=render",
  "pmcid": "PMC13739509",
  "pmid": "42996431",
  "published": "2026-10-23",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/e6jkz3cc12gq9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:13Z",
      "native_id": "fd063bc143f649b995fefefd5b10b4a9",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fmed.2026.1917675"
    },
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42996431",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996431"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Gut microbiota composition and dysbiosis signatures associated with complex gastrointestinal and urological conditions in neonates: a case series study",
  "title_text": "Gut microbiota composition and dysbiosis signatures associated with complex gastrointestinal and urological conditions in neonates: a case series study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/e6jkz3cc12gq9",
  "venue": "Frontiers in Medicine",
  "versions": []
}