{
  "abstract": "Sexual fate in vertebrates is generally considered developmentally fixed; however, teleost fishes exhibit remarkable flexibility in their reproductive systems. It remains unclear whether a fully differentiated gonochoristic vertebrate can undergo complete and functional sex reversal, or what molecular mechanisms could drive such reprogramming. Here, using the yellow drum (Nibea albiflora), a complete and functional female‐to‐male sex reversal is demonstrated in adulthood through three key mechanisms: (1) oocytes serve as guardians in the maintenance of ovarian fate, (2) ovarian germline stem cells retain spermatogenic potential and can produce sperm, and (3) ovarian somatic cells undergo complete transdifferentiation from granulosa/theca to Sertoli/Leydig lineages. This work provides the first evidence of functional female‐to‐male sex reversal in adult gonochoristic vertebrates, challenging existing paradigms about sexual fate fixation. Furthermore, these findings establish a novel experimental system for investigating vertebrate sexual plasticity and create a broadly representative model for sexual manipulation in teleost fishes.",
  "abstract_shown": true,
  "affiliations": [
    "Zhejiang Marine Fisheries Research Institute Zhoushan China",
    "Zhejiang Ocean University Zhoushan China",
    "Zhoushan Field Comprehensive Scientific Observation and Research Station Ministry of Agriculture and Rural Affairs Zhoushan China",
    "School of Marine Sciences Ningbo University Ningbo China",
    "School of Life Sciences Nanchang University Nanchang China",
    "Department of Molecular and Cell Biology and Biochemistry Brown University Providence Rhode Island USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yang Yang",
      "orcid": "0000-0002-5038-5872"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Liechao Yu"
    },
    {
      "affs": [
        4
      ],
      "name": "Wanchang Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Gary Wessel",
      "orcid": "0000-0002-1210-9279"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ruiyi Chen"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Weihua Hu",
      "orcid": "0000-0001-9032-5703"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Dongdong Xu",
      "orcid": "0000-0002-6935-9375"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e6kb4vp36tdky.bib",
  "cited_by": 0,
  "doi": "10.1002/advs.77027",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13477260/",
  "id": "e6kb4vp36tdky",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://doi.org/10.1002/advs.77027",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1314|Reproductive biology and impacts on aquatic species"
    ]
  ],
  "openalex": "W7203533209",
  "pdf_url": null,
  "pmcid": "PMC13477260",
  "pmid": "42603290",
  "published": "2026-08-15",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/e6kb4vp36tdky.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:23:14Z",
      "native_id": "PMC13477260",
      "source": "pmc",
      "url": "https://doi.org/10.1002/advs.77027"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1314|Reproductive biology and impacts on aquatic species",
      "subfield": "physiology"
    }
  ],
  "title": "Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation",
  "title_text": "Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:33Z",
  "url": "https://research.draconitic.com/paper/e6kb4vp36tdky",
  "venue": "Advanced Science",
  "versions": []
}