{
  "abstract": "Introduction: Nucleic acid testing (NAT) is an important component of transfusion safety because it reduces the diagnostic window period of transfusion-transmitted infections. Despite nationwide implementation of NAT in Brazil, comprehensive nationwide indicators describing its utilization, temporal trends, and regional distribution in the public blood network remain scarce. Objectives: To evaluate temporal trends, regional distribution, population-based rates, and the ratio of NAT procedures to blood collections in the Brazilian public blood network from 2014 to 2025. Materials and methods: An ecological time-series study was conducted using approved quantities of NAT procedures and blood collections for transfusion recorded in the Outpatient Information System of the Brazilian Unified Health System (SIA/SUS). Absolute frequencies, rates per 100,000 inhabitants, and the ratio of NAT procedures to blood collections were calculated. Temporal trends were assessed using Prais-Winsten regression, with annual percent change (APC) and 95% confidence intervals (95%CI). Results: From 2014 to 2025, 32,153,389 NAT procedures were approved. The Southeast accounted for 43.9% of all procedures, whereas the highest population-based rates were observed in the Central-West and the lowest in the North. National utilization remained stationary from 2015 to 2025 (APC = 1.3%; 95%CI: −0.3 to 2.9). In 2020, the number of procedures decreased by 13.8% compared with the previous year, followed by recovery in subsequent years. The NAT-to-collection ratio approached unity from 2017 onward and reached 1.02 in 2025. Discussion and Conclusions: NAT utilization remained stable in the Brazilian public blood network, with recovery after the reduction observed in 2020. Differences in population-based rates indicated persistent regional disparities. The NAT-to-collection ratio showed proximity between the aggregated volumes of molecular screening procedures and blood collections recorded in the SUS. These indicators can support the monitoring of transfusion safety, regional planning, and evaluation of blood-screening policies, although they do not directly measure confirmed infections or transfusion-transmitted events.",
  "abstract_shown": true,
  "affiliations": [
    "Universidade do Estado do Amazonas (UEA), Manaus, Brazil",
    "Universidade Federal do Amazonas (UFAM), Manaus, Brazil"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Erick Frota Gomes FIGUEIREDO"
    },
    {
      "affs": [
        1
      ],
      "name": "Ricardo FERREIRA-GOMES"
    },
    {
      "affs": [
        0
      ],
      "name": "Vitória Gabrielly Godinho de SIQUEIRA"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana Carolina SHUAN LACO"
    },
    {
      "affs": [
        0
      ],
      "name": "Gisely Cardoso de MELO"
    },
    {
      "affs": [
        1
      ],
      "name": "Silvania Da Conceição FURTADO"
    },
    {
      "affs": [
        0
      ],
      "name": "Anne Cristine Gomes de ALMEIDA"
    },
    {
      "affs": [
        1
      ],
      "name": "Allyson Guimarães da COSTA"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e72610emqgmvv.bib",
  "cited_by": 0,
  "doi": "10.1016/j.htct.2026.107152",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2531137926008990",
  "id": "e72610emqgmvv",
  "issns": [
    "2531-1379",
    "2531-1387"
  ],
  "landing_url": "https://doi.org/10.1016/j.htct.2026.107152",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC633-647.5"
    ],
    [
      "openalex",
      "1405|Blood donation and transfusion practices"
    ]
  ],
  "openalex": "W7223154998",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2531137926008990/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/e72610emqgmvv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:37Z",
      "native_id": "f503181f154b477881b19d8b6c8e1f21",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.htct.2026.107152"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC633-647.5",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "INDICATORS OF NUCLEIC ACID TESTING UTILIZATION IN THE BRAZILIAN PUBLIC BLOOD NETWORK: A NATIONWIDE ANALYSIS OF DATASUS DATA, 2014–2025",
  "title_text": "INDICATORS OF NUCLEIC ACID TESTING UTILIZATION IN THE BRAZILIAN PUBLIC BLOOD NETWORK: A NATIONWIDE ANALYSIS OF DATASUS DATA, 2014–2025",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:37Z",
  "url": "https://research.draconitic.com/paper/e72610emqgmvv",
  "venue": "Hematology, Transfusion and Cell Therapy",
  "versions": []
}