{
  "abstract": "Myelodysplastic neoplasms (MDS) are characterized by insufficient hematopoiesis and alterations of the bone marrow microenvironment. However, bone health in MDS has not been evaluated in a prospective, longitudinal setting. Within the Bone and Hematology in Elderly (BoHemE) study, bone mineral density (represented as T-score) and bone-specific serum markers were assessed in patients with MDS (n = 111; 36% female) and age-matched controls (n = 84; 55% female) at baseline and after 3 years. At baseline, patients with MDS had a lower T-score [−0.2; p < 0.05] compared to controls, which was mainly attributed to the lower T-score in women with MDS [−0.3; p < 0.05]. Furthermore, the DNMT3A mutation was associated with a lower T-score within the MDS cohort [−0.7; p < 0.05], but the occurrence in controls had no effect. Albumin-adjusted calcium and phosphate levels correlated with T-scores within the MDS cohort [p < 0.0001 and p < 0.01, respectively], independent of age, sex, MDS duration, IPSS-M score, or transfusion dependence. Quality of life was lower in patients with MDS [p < 0.01], and remained stable over 3 years, whereas T-scores declined [−0.3; p < 0.05]. The presence of osteoporosis was associated with poor overall survival in MDS [p < 0.01]. In conclusion, bone health should be evaluated as part of the diagnostic work-up and clinical management of MDS.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany",
    "Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany",
    "Medizinische Universität Lausitz – Carl Thiem, Cottbus, Germany",
    "Digital Health Cluster, Department for Digital Health, Economics & Policy, Hasso-Plattner Institute, University of Potsdam, Potsdam, Germany",
    "Department of Medicine I, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany",
    "German Cancer Consortium (DKTK), Partner Sites Dresden and Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany",
    "Department of Hematology, Cell Therapy, Hemostaseology, and Infectious Diseases, University Hospital, Leipzig, Germany",
    "Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany",
    "Department of Orthopedic Surgery, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany",
    "Division of Orthopedic, Trauma and Plastic Surgery, University Hospital, Leipzig, Germany",
    "Faculty of Medicine Carl Gustav Carus, Institute for Medical Informatics and Biometry, Dresden University of Technology, Dresden, Germany",
    "Center for Evidence-Based Healthcare, Medical Faculty and University Hospital Carl Gustav Carus, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Heike Weidner",
      "orcid": "0009-0001-6045-3349"
    },
    {
      "affs": [
        0
      ],
      "name": "Elena Tsourdi"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Anne Sophie Platzbecker"
    },
    {
      "affs": [
        0
      ],
      "name": "Martina Rauner",
      "orcid": "0000-0002-4067-6799"
    },
    {
      "affs": [
        0
      ],
      "name": "Ulrike Baschant"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria G. Ledesma-Colunga"
    },
    {
      "affs": [
        0
      ],
      "name": "Karolina Basiak",
      "orcid": "0009-0009-6367-8189"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Katja Sockel"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Ekaterina Balaian"
    },
    {
      "affs": [
        4
      ],
      "name": "Susann Winter",
      "orcid": "0000-0002-4228-4537"
    },
    {
      "affs": [
        4
      ],
      "name": "Anna Harig"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Klaus H. Metzeler",
      "orcid": "0000-0003-3920-7490"
    },
    {
      "affs": [
        5,
        7
      ],
      "name": "Katharina S. Götze",
      "orcid": "0000-0002-6276-8002"
    },
    {
      "affs": [
        6
      ],
      "name": "Dominic Brauer"
    },
    {
      "affs": [
        6
      ],
      "name": "Nicole Modler"
    },
    {
      "affs": [
        6
      ],
      "name": "Michael Cross",
      "orcid": "0000-0002-8815-7621"
    },
    {
      "affs": [
        6
      ],
      "name": "Marie Schneider",
      "orcid": "0000-0001-9022-5470"
    },
    {
      "affs": [
        8
      ],
      "name": "Jörg Lützner"
    },
    {
      "affs": [
        9
      ],
      "name": "Andreas Roth",
      "orcid": "0000-0002-1145-955X"
    },
    {
      "affs": [
        10
      ],
      "name": "Thomas Zerjatke",
      "orcid": "0000-0002-2125-9084"
    },
    {
      "affs": [
        11
      ],
      "name": "Gabriele Müller",
      "orcid": "0000-0002-1591-0539"
    },
    {
      "affs": [
        4,
        5,
        6
      ],
      "name": "Uwe Platzbecker",
      "orcid": "0000-0003-1863-3239"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Lorenz C. Hofbauer",
      "orcid": "0000-0002-8691-8423"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e7kedpnvnhbxz.bib",
  "cited_by": 0,
  "doi": "10.1038/s41375-026-03125-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13713548/",
  "id": "e7kedpnvnhbxz",
  "issns": [
    "0887-6924",
    "1476-5551"
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  "landing_url": "https://doi.org/10.1038/s41375-026-03125-8",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
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      "openalex",
      "2732|Bone health and osteoporosis research"
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  "pdf_url": "https://www.nature.com/articles/s41375-026-03125-8.pdf",
  "pmcid": "PMC13713548",
  "pmid": "42855472",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e7kedpnvnhbxz.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:24:04Z",
      "native_id": "PMC13713548",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41375-026-03125-8"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2732|Bone health and osteoporosis research",
      "subfield": "surgery"
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  ],
  "title": "Bone health in myelodysplastic neoplasms: results from the prospective longitudinal BoHemE study",
  "title_text": "Bone health in myelodysplastic neoplasms: results from the prospective longitudinal BoHemE study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:12Z",
  "url": "https://research.draconitic.com/paper/e7kedpnvnhbxz",
  "venue": "Leukemia",
  "versions": []
}