{
  "abstract": "Radiotherapy is a cornerstone of cancer treatment but is limited by injury to normal tissues. Radiation-induced ROS, DNA double-strand breaks, mitochondrial dysfunction, dysregulated DNA damage responses (DDR), and persistent inflammation drive acute and chronic toxicity. Radioprotective strategies must protect normal tissues without weakening tumor control. This review examines nanomedicine strategies for normal-tissue radioprotection through three mechanisms: (1) redox regulation by nanozymes, radical scavengers, and antioxidant delivery systems; (2) modulation of DDR pathways and cell fate; and (3) microbiome and metabolite regulation. We discuss how these strategies affect molecular damage, inflammation, and tissue repair and assess whether they preserve normal tissues without compromising antitumor immunity or radiotherapy efficacy.",
  "abstract_shown": true,
  "affiliations": [
    "School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.",
    "Department of Oncology, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.",
    "Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, 100020, People's Republic of China.",
    "Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.",
    "Department of Oncology, The Second People's Hospital of Neijiang, Neijiang, Sichuan, People's Republic of China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Han Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinrui Du"
    },
    {
      "affs": [
        2
      ],
      "name": "Chengyuan Zhou",
      "orcid": "0000-0001-5739-8222"
    },
    {
      "affs": [
        3
      ],
      "name": "Yue Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ke Su"
    },
    {
      "affs": [
        4
      ],
      "name": "Siyuan Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e7mdjn15m1wq6.bib",
  "cited_by": 0,
  "doi": "10.2147/ijn.s650755",
  "fulltext_url": "https://europepmc.org/articles/PMC13726714",
  "id": "e7mdjn15m1wq6",
  "issns": [
    "1176-9114",
    "1178-2013"
  ],
  "landing_url": "https://europepmc.org/article/MED/42974519",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2741|Effects of Radiation Exposure"
    ]
  ],
  "openalex": "W7224077971",
  "pdf_url": "https://europepmc.org/articles/PMC13726714?pdf=render",
  "pmcid": "PMC13726714",
  "pmid": "42974519",
  "published": "2026-10-29",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/e7mdjn15m1wq6.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974519",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974519"
    },
    {
      "first_seen": "2026-11-05T12:23:00Z",
      "native_id": "PMC13726714",
      "source": "pmc",
      "url": "https://doi.org/10.2147/ijn.s650755"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Effects of Radiation Exposure",
      "subfield": "imaging"
    }
  ],
  "title": "Mechanism-Driven Nanomedicine for Radiation Injury and Protection: Redox Homeostasis, the DNA Damage Response, and Microbiome-Based Strategies.",
  "title_text": "Mechanism-Driven Nanomedicine for Radiation Injury and Protection: Redox Homeostasis, the DNA Damage Response, and Microbiome-Based Strategies.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:36Z",
  "url": "https://research.draconitic.com/paper/e7mdjn15m1wq6",
  "venue": "International journal of nanomedicine",
  "versions": []
}