{
  "abstract": "Intrahepatic cholangiocarcinoma carries a poor prognosis making its management challenging. Histotripsy is a non-invasive, non-ionizing, and non-thermal therapy that mechanically disrupts tumors through acoustic cavitation. We present the case of a 59-year-old man with locally advanced, multifocal, stage II intrahepatic cholangiocarcinoma who achieved a complete pathologic response in the explanted liver after treatment with histotripsy and systemic drug therapy consisting of gemcitabine, cisplatin, durvalumab, and trastuzumab deruxtecan. This case highlights the potential role of noninvasive histotripsy as a bridging therapy to transplantation in selected patients with cholangiocarcinoma.",
  "abstract_shown": true,
  "affiliations": [
    "Leonard Cancer Institute, Providence Mission Hospital, Mission Viejo, CA, United States.",
    "Department of Interventional Radiology, Providence Mission Hospital, Mission Viejo, CA, United States.",
    "Liver Transplantation & HPB Surgery, Cleveland Clinic Foundation, Cleveland, OH, United States.",
    "Department of Neuro-Oncology, Providence Mission Hospital, Mission Viejo, CA, United States.",
    "Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, United States.",
    "Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, United States.",
    "JC Walter Jr Center for Transplantation, Houston Methodist Hospital, Houston, TX, United States.",
    "Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital, Houston, TX, United States."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tiffany M Juarez"
    },
    {
      "affs": [
        1
      ],
      "name": "Jimmy Ton"
    },
    {
      "affs": [
        1
      ],
      "name": "Ivan Babin"
    },
    {
      "affs": [
        2
      ],
      "name": "Chase J Wehrle"
    },
    {
      "affs": [
        1
      ],
      "name": "Victoria Chuchua"
    },
    {
      "affs": [
        3
      ],
      "name": "Santosh Kesari"
    },
    {
      "affs": [
        4
      ],
      "name": "Bin S Teh"
    },
    {
      "affs": [
        5
      ],
      "name": "Sadhna Dhingra"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Ashish Saharia"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Ashton Connor"
    },
    {
      "affs": [
        7
      ],
      "name": "Sudha Kodali"
    },
    {
      "affs": [
        1
      ],
      "name": "Kevin Burns"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e7v8tsxp11kc0.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1740407",
  "fulltext_url": "https://europepmc.org/articles/PMC13683007",
  "id": "e7v8tsxp11kc0",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42908588",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Cholangiocarcinoma and Gallbladder Cancer Studies"
    ]
  ],
  "openalex": "W7220868252",
  "pdf_url": "https://europepmc.org/articles/PMC13683007?pdf=render",
  "pmcid": "PMC13683007",
  "pmid": "42908588",
  "published": "2026-10-07",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/e7v8tsxp11kc0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42908588",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908588"
    },
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1740407",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1740407/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cholangiocarcinoma and Gallbladder Cancer Studies",
      "subfield": "surgery"
    }
  ],
  "title": "Complete response in unresectable HER2+ cholangiocarcinoma with histotripsy and systemic therapy followed by liver transplantation: a case report.",
  "title_text": "Complete response in unresectable HER2+ cholangiocarcinoma with histotripsy and systemic therapy followed by liver transplantation: a case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:13Z",
  "url": "https://research.draconitic.com/paper/e7v8tsxp11kc0",
  "venue": "Frontiers in oncology",
  "versions": []
}