{
  "abstract": "Introduction: Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) involve psychological symptoms that impact women’s quality of life. PMS pathogenesis is characterized by fluctuations in steroid hormones and γ-aminobutyric acid type A receptor (GABAAR) subunits. Kamishoyosan (KSS) is a Kampo medicine typically used to treat menstrual-related symptoms. This study aimed to elucidate the anxiolytic effect of KSS and its underlying mechanisms in a progesterone withdrawal (PWD)-induced PMS rat model.\n\nMethods: KSS was administered via feed mixing, and elevated plus maze test and molecular biological analysis were conducted.\n\nResults: PWD rats showed increased anxiety-like behavior and expression of GABAAR α4 and δ subunits mRNA in the hippocampal CA1 region, suggesting that decreased inhibitory GABA synaptic signaling contributes to anxiety-like behavior. KSS administration reduced anxiety-like behavior and the expression of GABAAR α4 and δ subunits, but no significant effect was observed on steroid hormone levels.\n\nDiscussion: These findings suggest that KSS exerts anxiolytic effects by reversing changes in α4 and δ subunit expression without affecting steroid hormone fluctuations. The different mechanism of action of KSS compared with GABAAR agonists may provide a novel therapeutic strategy for PMS.",
  "abstract_shown": true,
  "affiliations": [
    "TSUMURA Kampo Research Laboratories, TSUMURA & CO.",
    "TSUMURA Advanced Technology Research Laboratories, TSUMURA & CO.",
    "Research and Development Division, TSUMURA & CO."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shiori Harada-Nitta"
    },
    {
      "affs": [
        0
      ],
      "name": "Keisuke Ogura"
    },
    {
      "affs": [
        1
      ],
      "name": "Kunihiro Konno"
    },
    {
      "affs": [
        0
      ],
      "name": "Miwa Nahata"
    },
    {
      "affs": [
        0
      ],
      "name": "Naoki Fujitsuka"
    },
    {
      "affs": [
        2
      ],
      "name": "Yohei Tokita"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e81wywqmkwsyk.bib",
  "cited_by": 0,
  "doi": "10.3389/fpsyt.2026.1799904",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720535/?tool=EBI",
  "id": "e81wywqmkwsyk",
  "issns": [
    "1664-0640"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1799904/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2707|Medicinal Plant Extracts Effects"
    ]
  ],
  "openalex": "W7222761787",
  "pdf_url": "https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1799904/pdf",
  "pmcid": "PMC13720535",
  "pmid": "42964414",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/e81wywqmkwsyk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:18Z",
      "native_id": "10.3389/fpsyt.2026.1799904",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1799904/full"
    },
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13720535",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13720535"
    },
    {
      "first_seen": "2026-11-03T12:21:24Z",
      "native_id": "PMC13720535",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fpsyt.2026.1799904"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-0640",
      "subfield": "psychiatry"
    }
  ],
  "title": "Kamishoyosan reduces anxiety-like behavior by modulating GABAA receptor subunit expression in a premenstrual syndrome rat model",
  "title_text": "Kamishoyosan reduces anxiety-like behavior by modulating GABAA receptor subunit expression in a premenstrual syndrome rat model",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:24Z",
  "url": "https://research.draconitic.com/paper/e81wywqmkwsyk",
  "venue": "Frontiers in Psychiatry",
  "versions": []
}