{
  "abstract": "Complete connectomes now exist for insect nervous systems, but whether a fixed wiring diagram can learn, and what its memories consist of, is unknown. Here, we trained a spiking model of the whole male Drosophila central nervous system, 167,106 neurons with fixed wiring, to plan moves and to remember a visual cue. Spikes write the cue into neuronal adaptation, which holds it silently until the next input reads it out. Cells that hold the trace are enriched for transcripts of a calcium-activated potassium channel in fly cell atlases. The learned readout recalls the trace only in the brain state of learning: the same trace evokes a different response at another delay, and a disease-like loss of potassium current rewrites the trace and changes how it is read. Learning in the new state is spared. Memory failure can arise from a change of state rather than a loss of storage.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology, Otolaryngology Research Center, and Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang,"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "name": "H. Wang"
    },
    {
      "name": "J. P. S. Yeong"
    },
    {
      "name": "Y. Zhao"
    },
    {
      "name": "Y. Zhao"
    },
    {
      "name": "Z. Yu"
    },
    {
      "name": "X. Liu"
    },
    {
      "name": "R. He"
    },
    {
      "name": "H. Chen"
    },
    {
      "name": "T. Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Y. Tian"
    },
    {
      "name": "W. Chen"
    },
    {
      "name": "Y. Cai"
    },
    {
      "name": "Y. Xu"
    },
    {
      "name": "H. Ning"
    },
    {
      "name": "X. Hou"
    },
    {
      "name": "L. Pang"
    },
    {
      "name": "D. Jiang"
    },
    {
      "name": "H. Liu"
    },
    {
      "name": "J. Hao"
    },
    {
      "affs": [
        0
      ],
      "name": "C. Tian"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e86t54k8hjg91.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.24.761586",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.24.761586v1.full",
  "id": "e86t54k8hjg91",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.24.761586v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.24.761586v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e86t54k8hjg91.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:30:19Z",
      "native_id": "10.64898/2026.10.24.761586",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.24.761586v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Brain state locks silent memories in a trained fly connectome",
  "title_text": "Brain state locks silent memories in a trained fly connectome",
  "type": "preprint",
  "updated_at": "2026-10-31T00:20:36Z",
  "url": "https://research.draconitic.com/paper/e86t54k8hjg91",
  "venue": "bioRxiv",
  "versions": []
}