{
  "abstract": "Background: Community-acquired intra-abdominal infections (CA-IAIs) exhibit significant clinical heterogeneity. However, most studies focusing on CA-IAIs do not stratify comparisons by infection site. Methods: This post hoc analysis of the prospective multicenter PERICOM cohort (13 French university hospitals, April 2018 to February 2019) included adult patients with CA-IAIs requiring surgical management. We compared clinical characteristics, microbiology, and outcomes between appendicular and non-appendicular sites. Secondary analyses assessed the impact of Enterococcus spp., Pseudomonas aeruginosa, or fungal documentation, and the theoretical coverage of empirical antibiotic regimens. Results: Of the 205 patients, 86 (42%) had appendicular and 119 (58%) had non-appendicular CA-IAIs. Appendicular CA-IAIs involved younger patients with fewer comorbidities and were followed by fewer major postoperative complications (Clavien-Dindo score ≥ 3: 10% versus 43%, p < 0.001) and no deaths (0% versus 12%, p < 0.001). Among 118 culture-positive patients, appendicular CA-IAIs showed higher rates of non-fermenting Gram-negative bacilli (25% versus 10%, p = 0.046) and anaerobes (53% versus 28%, p = 0.008) and were more often polymicrobial (76% versus 55%, p = 0.020). Conversely, Staphylococcus spp. (0% versus 9%, p = 0.036) and fungal co-infection (0% versus 12%, p = 0.010) were confined to non-appendicular CA-IAIs. Furthermore, Enterococcus spp. documentation (24/118, 20%) identified patients with greater admission severity and higher 28-day mortality (33% versus 2%, p < 0.001). Amoxicillin-clavulanic acid plus gentamicin covered the isolates of 92% of patients versus 61% for third-generation cephalosporin plus metronidazole (p < 0.001), a difference identical in both appendicular and non-appendicular sites. Conclusions: Appendicular and non-appendicular CA-IAIs appear to be distinct entities, supporting stratified management. Future guidelines should consider site-specific strategies, therapeutic individualization, and the integration of CA-IAI ecology.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "name": "Arthur Chouaikhi-Perrois"
    },
    {
      "name": "Nicolas Boulet"
    },
    {
      "name": "Samy Figueiredo"
    },
    {
      "name": "Benjamin Louart"
    },
    {
      "name": "Delphine Garrigue"
    },
    {
      "name": "Guillaume Bouhours"
    },
    {
      "name": "Hervé Dupont"
    },
    {
      "name": "Pierre Bouzat"
    },
    {
      "name": "Jean Bardon"
    },
    {
      "name": "Julien Pottecher"
    },
    {
      "name": "Pierre Michelet"
    },
    {
      "name": "Sébastien Perbet"
    },
    {
      "name": "Katia Aymart"
    },
    {
      "name": "Pascal Incagnoli"
    },
    {
      "name": "Sophie Lloret"
    },
    {
      "name": "Anatole Harrois"
    },
    {
      "name": "Philippe Montravers"
    },
    {
      "name": "Claire Roger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e8ezastgnnw0z.bib",
  "cited_by": 0,
  "doi": "10.3390/antibiotics15090910",
  "fulltext_url": null,
  "id": "e8ezastgnnw0z",
  "issns": [
    "2079-6382"
  ],
  "landing_url": "https://u-picardie.hal.science/hal-05757869v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.heg"
    ],
    [
      "hal",
      "2.sdv.mhep.mi"
    ],
    [
      "openalex",
      "2711|Appendicitis Diagnosis and Management"
    ]
  ],
  "openalex": "W7213327754",
  "pdf_url": "https://u-picardie.hal.science/hal-05757869/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-16",
  "publisher": "MDPI",
  "ris": "https://research.draconitic.com/paper/e8ezastgnnw0z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:37Z",
      "native_id": "hal-05757869",
      "source": "hal",
      "url": "https://u-picardie.hal.science/hal-05757869v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.mi",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Appendicular Versus Non-Appendicular Community-Acquired Intra-Abdominal Infections: A Post-Hoc Analysis of the PERICOM Multicenter Study",
  "title_text": "Appendicular Versus Non-Appendicular Community-Acquired Intra-Abdominal Infections: A Post-Hoc Analysis of the PERICOM Multicenter Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:37Z",
  "url": "https://research.draconitic.com/paper/e8ezastgnnw0z",
  "venue": "Antibiotics",
  "versions": []
}