{
  "abstract": "In comparison to well-documented methods for accessing α-C-aryl glycosides,the stereoselective synthesis ofβ-anomers remains challenging, as less reliable routes to β-functionalisation are established. Metal-catalyzed cross-coupling is known as one of the most straightforward methods to afford stereoselectively β-C-aryl glycosides, this strategy often requires the use of elaborated glycosyl donors or sensitive aryl metals along with the use of strict anhydrous and oxygen-free conditions. Herein, we report a robust and stereoselective synthesis of β-C-aryl glycosides by Ni-catalyzed reductive cross-coupling using readily available and bench-stable materials. This reaction couples glycosyl halides and aryl halides in the presence of an air-stable Ni⁰ pre-catalyst and a mild reductant. The reaction exhibits excellent β-stereoselectivity with a broad range of carbohydrates and aryl moieties. Mechanistic studies, supported by density functional theory calculations, were performed to provide a rationale for the observed β-stereoselectivity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Victor Crespin"
    },
    {
      "name": "Abir Jertila"
    },
    {
      "name": "Eric Daiann Sosa Carrizo"
    },
    {
      "name": "Elsa van Elslande"
    },
    {
      "name": "Tanguy Saget"
    },
    {
      "name": "Stéphanie Norsikian"
    },
    {
      "name": "Marie Sircoglou"
    },
    {
      "name": "Sébastien Vidal"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e8mgqj2azkawx.bib",
  "cited_by": 0,
  "doi": "10.1002/ceur.202500477",
  "fulltext_url": null,
  "id": "e8mgqj2azkawx",
  "issns": [
    "2751-4765"
  ],
  "landing_url": "https://hal.science/hal-05740111v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.cata"
    ],
    [
      "hal",
      "1.chim.orga"
    ],
    [
      "openalex",
      "1605|Carbohydrate Chemistry and Synthesis"
    ]
  ],
  "openalex": "W7140290126",
  "pdf_url": "https://hal.science/hal-05740111/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-06",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/e8mgqj2azkawx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:29Z",
      "native_id": "hal-05740111",
      "source": "hal",
      "url": "https://hal.science/hal-05740111v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.cata",
      "subfield": "catalysis"
    },
    {
      "field": "chemistry",
      "origin": "hal:1.chim.orga",
      "subfield": "organic"
    }
  ],
  "title": "Stereoselective β‐C‐aryl Glycosylation Through Ni‐Catalyzed Reductive Cross‐Coupling",
  "title_text": "Stereoselective β‐C‐aryl Glycosylation Through Ni‐Catalyzed Reductive Cross‐Coupling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:29Z",
  "url": "https://research.draconitic.com/paper/e8mgqj2azkawx",
  "venue": "ChemistryEurope",
  "versions": []
}