{
  "abstract": "Background: Neoadjuvant chemotherapy (NAC) may influence systemic metabolic-inflammatory status before surgery; however, the association between preoperative biomarker profiles and early recovery after immediate breast reconstruction remains incompletely understood.\n\nMethods: In our retrospective study, we included 214 patients who had immediate breast reconstruction; out of them, 102 patients received NAC, and the other 112 patients didn’t. Preoperative measurements of serum albumin, C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio (NLR) were performed. The main outcome was prolonged hospitalization, defined as a length of stay (LOS) greater than the cohort median of 8 days; postoperative complications were evaluated separately. Factors associated with prolonged hospitalization were analyzed using multiple logistic regression, and the model’s discrimination was assessed using receiver operating characteristic (ROC) analysis.\n\nResults: Overall, 93 patients (43.5%) experienced prolonged hospitalization. Patients who received NAC were hospitalized longer than those who didn’t (8.6 ± 2.9 days vs 7.2 ± 2.4 days; P = 0.001), and NAC patients also had more complications (28.4% vs 17.0%; P = 0.045). In the multivariable analysis, NAC exposure (OR = 1.82, 95% CI: 1.08–3.05; P = 0.024) and a higher NLR (OR = 1.36, 95% CI: 1.12–1.65; P = 0.002) were independently related to longer length of stay, while a greater level of albumin was negatively related to length of stay (OR = 0.94, 95% CI: 0.90–0.98; P = 0.006). The multivariable model had fair discrimination (AUC = 0.742, 95% CI: 0.676–0.808).\n\nConclusions: Preoperative albumin and NLR levels may help identify patients at greater risk of prolonged hospitalization; further study is needed for multicenter validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Breast Surgery, Shanxi Cancer Hospital; Cancer Hospital of Chinese Academy of Medical Sciences (Shanxi Hospital); Affiliated Cancer Hospital of Shanxi Medical University",
    "Department of Radiation Therapy, Thoracic Radiotherapy Ward III, Shanxi Provincial Cancer Hospital / Shanxi Hospital, Cancer Hospital, Chinese Academy of Medical Sciences / Third People's Hospital Affiliated to Shanxi Medical University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fan Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lan Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Bai"
    },
    {
      "affs": [
        1
      ],
      "name": "Chengyu Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongmin Miao"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenfu Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e8x1n5w3cvyr5.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1921109",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1921109/full",
  "id": "e8x1n5w3cvyr5",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1921109/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC648-665"
    ],
    [
      "openalex",
      "2746|Breast Implant and Reconstruction"
    ]
  ],
  "openalex": "W7223709235",
  "pdf_url": "https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1921109/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/e8x1n5w3cvyr5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.3389/fendo.2026.1921109",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1921109/full"
    },
    {
      "first_seen": "2026-10-30T13:47:17Z",
      "native_id": "0ed781f7fde3480db60b6ec3023e6fdf",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fendo.2026.1921109"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Breast Implant and Reconstruction",
      "subfield": "surgery"
    }
  ],
  "title": "Preoperative metabolic–inflammatory profiles and early postoperative recovery after immediate breast reconstruction in patients with and without neoadjuvant chemotherapy: a retrospective cohort study",
  "title_text": "Preoperative metabolic–inflammatory profiles and early postoperative recovery after immediate breast reconstruction in patients with and without neoadjuvant chemotherapy: a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:21:07Z",
  "url": "https://research.draconitic.com/paper/e8x1n5w3cvyr5",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}