{
  "abstract": "A novel calcium-chelating peptide, KTFQGPPHG, was identified and screened from Moringa oleifera Lam. leaf protein hydrolysate, and further used to prepare a highly stable peptide-calcium chelate (KTFQGPPHG-Ca). The structure of KTFQGPPHG-Ca was characterized, while assessing its chelation stability and calcium transport potential. It was found that the calcium binding capacity of KTFQGPPHG reached 62.401 µg/mg. After chelation with calcium, KTFQGPPHG transitioned from an amorphous structure to a stable crystalline form. Carboxyl oxygen atoms and amino nitrogen atoms on KTFQGPPHG served as binding sites for Ca²⁺. The KTFQGPPHG-Ca demonstrates excellent phosphate stability and thermal stability. In addition, the calcium transport amount of KTFQGPPHG at 30 min and 60 min was significantly higher than that of the CaCl₂ group (p < 0.05). Particularly, the calcium transport capacity at 30 min was 1.40-fold that of the CaCl₂ group. KTFQGPPHG effectively counteracted the suppressive impact of dietary factors on Ca²⁺ absorption, and likely promoted Ca²⁺ translocation via the TRPV6 calcium channel pathway. The present results offer a theoretical basis for KTFQGPPHG-Ca to serve as a promising calcium source to improve intestinal calcium absorption.",
  "abstract_shown": true,
  "affiliations": [
    "College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.",
    "Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.",
    "Yunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ruijing Gu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zilin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Zhou"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jiahe Dai"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Lei Peng",
      "orcid": "0000-0003-4315-4897"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Yang Tian"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Liang Tao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e92c12wj6dewk.bib",
  "cited_by": 0,
  "doi": "10.3390/foods15193496",
  "fulltext_url": "https://europepmc.org/articles/PMC13664339",
  "id": "e92c12wj6dewk",
  "issns": [
    "2304-8158"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883604",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Protein Hydrolysis and Bioactive Peptides"
    ]
  ],
  "openalex": "W7214708830",
  "pdf_url": "https://europepmc.org/articles/PMC13664339?pdf=render",
  "pmcid": "PMC13664339",
  "pmid": "42883604",
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/e92c12wj6dewk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883604",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883604"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Protein Hydrolysis and Bioactive Peptides",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Moringa oleifera Lam. Leaf Peptide-Calcium Chelates: Structural Characterization, Stability and Calcium Absorption-Promoting Transport Capability.",
  "title_text": "Moringa oleifera Lam. Leaf Peptide-Calcium Chelates: Structural Characterization, Stability and Calcium Absorption-Promoting Transport Capability.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/e92c12wj6dewk",
  "venue": "Foods (Basel, Switzerland)",
  "versions": []
}