{
  "abstract": "INTRODUCTION: Multiple plasma phosphorylated tau assays are now commercially available for Alzheimer's disease (AD), yet clinical laboratories lack comprehensive comparative data to guide implementation.\n\nMETHODS: We assessed diagnostic accuracy and analytical performance in 273 participants with paired plasma and cerebrospinal fluid (CSF). CSF AD core biomarkers served as the reference standard. Index tests included three plasma tau phosphorylated at residue 217 (pTau217) assays (Roche, Fujirebio, Meso Scale Discovery [MSD]) and a pTau181 assay (Roche).\n\nRESULTS: Participants: median age 70 [IQR: 64 to 76] years, 42% female, and 60% AD‐positive. pTau217 assays showed comparable accuracy (area under the curve [AUC] 0.88 to 0.89) exceeding pTau181 (AUC 0.85). All assays were resistant to hemolysis, icterus, and lipemia. Automated assays (Roche, Fujirebio) showed superior analytical precision and freeze/thaw stability (≥6 cycles) compared to the manual MSD assay (two cycles).\n\nDISCUSSION: With comparable diagnostic accuracy across pTau217 platforms, analytical performance, and operational suitability became decisive implementation differentiators.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada",
    "Department of Psychiatry University of British Columbia Vancouver Canada",
    "Division of Neurology Department of Medicine University of British Columbia Vancouver Canada",
    "Department of Pathology and Laboratory Medicine St. Paul's Hospital Providence Health Care Vancouver Canada"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Olga Sandoval‐Boczkowska",
      "orcid": "0009-0001-6071-7703"
    },
    {
      "affs": [
        1
      ],
      "name": "John R. Best",
      "orcid": "0000-0001-5775-7053"
    },
    {
      "affs": [
        2
      ],
      "name": "Rachael J. Y. Smith",
      "orcid": "0009-0006-7720-3369"
    },
    {
      "affs": [
        3
      ],
      "name": "Laura Burns"
    },
    {
      "affs": [
        0
      ],
      "name": "Cyril Helbling",
      "orcid": "0000-0002-9518-509X"
    },
    {
      "affs": [
        2
      ],
      "name": "Ging‐Yuek Robin Hsiung",
      "orcid": "0000-0002-8017-0856"
    },
    {
      "affs": [
        2
      ],
      "name": "Jacqueline A. Pettersen",
      "orcid": "0000-0001-7232-7377"
    },
    {
      "affs": [
        2
      ],
      "name": "Philip E. Lee"
    },
    {
      "affs": [
        2
      ],
      "name": "Alexandre Henri‐Bhargava"
    },
    {
      "affs": [
        2
      ],
      "name": "Haakon B. Nygaard",
      "orcid": "0000-0001-5085-4723"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Mari L. DeMarco",
      "orcid": "0000-0001-9281-9547"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e9er8a749tsbs.bib",
  "cited_by": 0,
  "doi": "10.1002/dad2.70465",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13728325/",
  "id": "e9er8a749tsbs",
  "issns": [
    "2352-8729"
  ],
  "landing_url": "https://doi.org/10.1002/dad2.70465",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7160410885",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.70465",
  "pmcid": "PMC13728325",
  "pmid": "42979019",
  "published": "2026-11-02",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/e9er8a749tsbs.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:24:02Z",
      "native_id": "PMC13728325",
      "source": "pmc",
      "url": "https://doi.org/10.1002/dad2.70465"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Multi‐platform comparison of plasma phosphorylated tau assays: analytical and workflow factors drive clinical implementation decisions",
  "title_text": "Multi‐platform comparison of plasma phosphorylated tau assays: analytical and workflow factors drive clinical implementation decisions",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:20Z",
  "url": "https://research.draconitic.com/paper/e9er8a749tsbs",
  "venue": "Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring",
  "versions": []
}