{
  "abstract": "Prostate cancer (PCa) remains one of the most prevalent malignancies and a leading cause of cancer-related mortality among men worldwide. Despite advancements in treatment, therapeutic resistance, particularly to docetaxel (DTX), significantly limits clinical efficacy and worsens patient outcomes. Transcriptomic profiles and matched clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were integrated for analysis. Differentially expressed genes linked to DTX resistance were screened to classify PCa patients into molecular subtypes. Bulk transcriptome-based drug sensitivity estimation and immune pathway enrichment analysis were performed to compare subtype-specific features. Single-cell transcriptomic data were further applied to resolve epithelial cell heterogeneity and interrogate the biological function of AMH in DTX-resistant epithelial subpopulations. Two discrete molecular subtypes (C1 and C2) were established based on DTX resistance-related gene signatures. The C1 subtype displayed an aggressive phenotype with shorter progression-free survival (PFS), unique mutational landscapes, and activated immunosuppressive pathways. Subtypes also showed divergent sensitivity to multiple anticancer agents. Single-cell results demonstrated that AMH-high epithelial cells had low proliferation activity, limited genomic instability and weak DTX resistance. In contrast, AMH-low epithelial subpopulations were highly proliferative, carried a heavier mutational burden, and exhibited hyperactive intercellular communication dominated by VEGF signaling. Collectively, these findings highlight the cellular and molecular heterogeneity associated with DTX resistance in PCa and provide new insights into the molecular characteristics of DTX resistance. These results may facilitate the identification of candidate biomarkers and potential therapeutic targets, although further experimental and clinical validation is required.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer Hospital, Changsha, China.",
    "Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.",
    "Department of Colorectal and Anorectal Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou Central Hospital, Zhuzhou, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Liang Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shusuan Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Gongqian Zeng"
    },
    {
      "affs": [
        0
      ],
      "name": "Jun Gao"
    },
    {
      "affs": [
        1
      ],
      "name": "Hong Shan"
    },
    {
      "affs": [
        2
      ],
      "name": "Ke Huang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e9h584yymeswx.bib",
  "cited_by": 0,
  "doi": "10.21037/tau-2026-0290",
  "fulltext_url": "https://europepmc.org/articles/PMC13743362",
  "id": "e9h584yymeswx",
  "issns": [
    "2223-4691"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999584",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "1306|Prostate Cancer Treatment and Research"
    ]
  ],
  "openalex": "W7223972940",
  "pdf_url": "https://europepmc.org/articles/PMC13743362?pdf=render",
  "pmcid": "PMC13743362",
  "pmid": "42999584",
  "published": "2026-09-28",
  "publisher": "AME Publications",
  "ris": "https://research.draconitic.com/paper/e9h584yymeswx.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42999584",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999584"
    },
    {
      "first_seen": "2026-11-10T12:24:07Z",
      "native_id": "PMC13743362",
      "source": "pmc",
      "url": "https://doi.org/10.21037/tau-2026-0290"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Prostate Cancer Treatment and Research",
      "subfield": "oncology"
    }
  ],
  "title": "Comprehensive multi-omics analysis identifies molecular subtypes and AMH-dependent mechanisms driving DTX resistance in prostate cancer.",
  "title_text": "Comprehensive multi-omics analysis identifies molecular subtypes and AMH-dependent mechanisms driving DTX resistance in prostate cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:24:07Z",
  "url": "https://research.draconitic.com/paper/e9h584yymeswx",
  "venue": "Translational andrology and urology",
  "versions": []
}