{
  "abstract": "Indolizine scaffolds have attracted considerable interest owing to their broad potential in medicinal chemistry. In this work, we describe an original strategy for functionalizing the C-3 position of the indolizine core through a light-mediated three-component trifluoroalkylation reaction. This approach eliminates the need for a photocatalyst, enabling reactions to be conducted under milder and more environmentally friendly conditions than conventional trifluoroalkylation methods. Based on mechanistic investigations, we propose that the reaction proceeds via the in situ formation of an electron donor-acceptor (EDA) complex. The successful incorporation of a wide range of substituents at the C-3 position demonstrates the versatility and robustness of the developed protocol, enabling the synthesis of 20 trifluoromethylindolizine derivatives with yields up to 82%. Overall, this methodology simplifies access to C-3 functionalized indolizines and facilitates the exploration of new structures of potential biological interest.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Corinne Coutant"
    },
    {
      "name": "Konan Jean‐fabrice Koffi"
    },
    {
      "name": "Lielou Lantigner"
    },
    {
      "name": "Pascal Retailleau"
    },
    {
      "name": "Christian Herrero"
    },
    {
      "name": "Christine Tran"
    },
    {
      "name": "Abdallah Hamze"
    },
    {
      "name": "Sandrine Piguel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e9q9setxvezk3.bib",
  "cited_by": 0,
  "doi": "10.1002/ejoc.70921",
  "fulltext_url": null,
  "id": "e9q9setxvezk3",
  "issns": [
    "1434-193X",
    "1099-0690"
  ],
  "landing_url": "https://hal.science/hal-05847997v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7163005049",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ejoc.70921",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Wiley-VCH Verlag",
  "ris": "https://research.draconitic.com/paper/e9q9setxvezk3.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:20:44Z",
      "native_id": "hal-05847997",
      "source": "hal",
      "url": "https://hal.science/hal-05847997v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Photocatalyst‐Free Trifluoromethylation of Indolizines Through an Electron Donor–Acceptor Complex",
  "title_text": "Photocatalyst‐Free Trifluoromethylation of Indolizines Through an Electron Donor–Acceptor Complex",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:48Z",
  "url": "https://research.draconitic.com/paper/e9q9setxvezk3",
  "venue": "European Journal of Organic Chemistry",
  "versions": []
}