{
  "abstract": "We present a swept-source visible-light optical coherence tomography (SS-vis-OCT) system with twice the imaging depth of prior SS-vis-OCT and improved sensitivity for imaging biological samples, achieving shot-noise-limited operation. Because second-harmonic generation is limited by the booster optical amplifier's output power, the visible-light SS power is capped at 450 W. Increasing it further would require a more powerful, but costlier, amplifier. Instead, we reduce the receiver noise floor by selecting a balanced detector with NEP approaching the thermal (Johnson-Nyquist) limit. Real-time numerical k-linearization increases the effective number of linear-in-wavenumber samples per sweep, further improving SNR and extending the imaging range. Together, these improvements yield a sensitivity of 89 dB and an imaging depth of 9 mm in air or 6.5 mm in tissue, enabling full anterior-segment imaging of ex vivo porcine eyes.",
  "abstract_shown": true,
  "affiliations": [
    "Northwestern University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "W. Fan"
    },
    {
      "name": "R. Kuranov"
    },
    {
      "name": "M. Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "J. Zhang"
    },
    {
      "name": "F. Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "H. F. Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e9r9n7zj2k4wv.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.16.759740",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.16.759740v1.full",
  "id": "e9r9n7zj2k4wv",
  "issns": [
    "2692-8205"
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  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.16.759740v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioengineering"
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    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2204|Optical Coherence Tomography Applications"
    ]
  ],
  "openalex": "W7222982885",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.16.759740v1.full.pdf",
  "pmcid": "PMC13738544",
  "pmid": "42995957",
  "published": "2026-10-16",
  "publisher": "Cold Spring Harbor Laboratory Preprints",
  "ris": "https://research.draconitic.com/paper/e9r9n7zj2k4wv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:37Z",
      "native_id": "10.64898/2026.10.16.759740",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.16.759740v1"
    },
    {
      "first_seen": "2026-11-09T12:23:30Z",
      "native_id": "PMC13738544",
      "source": "pmc",
      "url": "https://doi.org/10.64898/2026.10.16.759740"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioengineering",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Imaging biological tissue at extended depth using swept-source visible-light OCT",
  "title_text": "Imaging biological tissue at extended depth using swept-source visible-light OCT",
  "type": "preprint",
  "updated_at": "2026-11-09T12:23:30Z",
  "url": "https://research.draconitic.com/paper/e9r9n7zj2k4wv",
  "venue": "bioRxiv",
  "versions": []
}