{
  "abstract": "Context: Postoperative pain and persistent microbial contamination remain significant challenges in pediatric endodontics following pulpectomy. Intracanal cryotherapy has emerged as a promising adjunct because of its anti-inflammatory, analgesic, and antimicrobial properties. However, its effectiveness requires further clinical evaluation. Aim: The aim of the study was to compare the effect of intracanal cryotherapy using cold saline (2°C–4°C) with room temperature saline (25°C–30°C) on postoperative pain and antimicrobial efficacy during the pulpectomy procedure in primary teeth. Settings and Design: A randomized clinical trial was conducted involving 30 children (3–7 years) requiring pulpectomy in primary teeth. Materials and Methods: Participants were randomly allocated into two groups: Group I (room temperature saline) and Group II (cryotherapy with cold saline). Postoperative pain was assessed using the Wong–Baker Faces Pain Rating Scale at 6, 24, 48, and 72 h posttreatment. Antimicrobial efficacy was evaluated by comparing colony-forming units (CFUs) before and after irrigation via microbiological analysis. Statistical Analysis: Data were analyzed using SPSS v26.0. Paired t- tests/Wilcoxon for intragroup; independent t-test/Mann–Whitney for intergroup were applied. Results: Both groups showed significant intragroup pain reduction over 6, 24, 48, and 72 h (P < 0.05), with cryotherapy exhibiting lower mean scores but no intergroup differences (P > 0.05). Microbial counts decreased significantly within groups (P = 0.001: Group I: 4.23–2.21 and Group II: 3.69–0.68), with cryotherapy superior postintervention (P < 0.001). No baseline differences were existed. Conclusions: Intracanal cryotherapy with cold saline is an effective, simple, and cost-efficient method for reducing postoperative pain and enhancing antimicrobial efficacy in primary teeth pulpectomy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Itika Jain"
    },
    {
      "name": "Shivani Mathur"
    },
    {
      "name": "Sakshi Joshi"
    },
    {
      "name": "Diksha Bhat"
    },
    {
      "name": "Shikha Choubey"
    },
    {
      "name": "Urvashi Verma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/e9tmbr0z42ctj.bib",
  "cited_by": 0,
  "doi": "10.4103/jisppd.jisppd_358_26",
  "fulltext_url": "https://www.ovid.com/jnls/pedprevden/fulltext/10.4103/jisppd.jisppd_358_26~impact-of-intracanal-cryotherapy-on-postoperative-pain-and",
  "id": "e9tmbr0z42ctj",
  "issns": [
    "0970-4388",
    "1998-3905"
  ],
  "landing_url": "https://doi.org/10.4103/jisppd.jisppd_358_26",
  "language": "en",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RK1-715"
    ],
    [
      "openalex",
      "3504|Endodontics and Root Canal Treatments"
    ]
  ],
  "openalex": "W7214035998",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Wolters Kluwer Medknow Publications",
  "ris": "https://research.draconitic.com/paper/e9tmbr0z42ctj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "046ab49e3b064225a456e86b06ccc418",
      "source": "doaj",
      "url": "https://doi.org/10.4103/jisppd.jisppd_358_26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RK1-715",
      "subfield": "general"
    }
  ],
  "title": "Impact of intracanal cryotherapy on postoperative pain and antimicrobial efficacy in primary teeth: A randomized clinical trial",
  "title_text": "Impact of intracanal cryotherapy on postoperative pain and antimicrobial efficacy in primary teeth: A randomized clinical trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:50Z",
  "url": "https://research.draconitic.com/paper/e9tmbr0z42ctj",
  "venue": "Journal of Indian Society of Pedodontics and Preventive Dentistry",
  "versions": []
}