{
  "abstract": "Acute basophilic leukemia (ABL) transformed from myelodysplastic syndrome is exceedingly rare. We report the case of a 73-year-old man with ABL which transformed from IPSS-M High risk MDS. The patient had a history of metastatic castration-sensitive prostate cancer. Further investigations demonstrated circulating blasts on peripheral blood smear. Upon bone marrow examination, a diagnosis of ABL arising from underlying MDS was established, characterized by cytogenetic analysis demonstrating trisomy 8 (+ 8), with the additional copy of chromosome 8 present in the form of a ring chromosome, and a WT1 frameshift mutation. The patient was treated with azacitidine and venetoclax, followed by best supportive care after disease progression. This case highlights the rare occurrence of ABL secondary to MDS and provides insight into the diagnostic challenges, clonal evolution, and therapeutic limitations associated with this aggressive entity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Haematology, Tan Tock Seng Hospital, Singapore, Singapore.",
    "Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.",
    "Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.",
    "Leukemia Department, MD Anderson Cancer Centre, Houston, TX, USA.",
    "Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore, Singapore.",
    "Department of Haematology-Oncology, National University Hospital, Singapore, Singapore.",
    "Division of Haematology, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.",
    "Department of Haematology, Tan Tock Seng Hospital, Singapore, Singapore. Bingwen.Eugene.Fan@nhghealth.com.sg.",
    "Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Bingwen.Eugene.Fan@nhghealth.com.sg.",
    "Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Bingwen.Eugene.Fan@nhghealth.com.sg.",
    "Northern Pathology Victoria, Department of Haematology, Northern Health, Melbourne, Australia. Bingwen.Eugene.Fan@nhghealth.com.sg."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Christian Aledia Gallardo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu Yue Hew"
    },
    {
      "affs": [
        3
      ],
      "name": "Wei-Ying Jen"
    },
    {
      "affs": [
        0
      ],
      "name": "Shanmugam Hemalatha"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao Wei Ang"
    },
    {
      "affs": [
        0
      ],
      "name": "Pik Wan Erica Chiang"
    },
    {
      "affs": [
        4
      ],
      "name": "Kian Guan Eric Lim"
    },
    {
      "affs": [
        0
      ],
      "name": "Jia En Iris Leow"
    },
    {
      "affs": [
        2,
        5,
        6
      ],
      "name": "Shir Ying Lee"
    },
    {
      "affs": [
        7,
        8,
        9,
        10
      ],
      "name": "Bingwen Eugene Fan",
      "orcid": "0000-0003-4367-5182"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ea78fk7hw2pw6.bib",
  "cited_by": 0,
  "doi": "10.1007/s00277-026-07206-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13680519",
  "id": "ea78fk7hw2pw6",
  "issns": [
    "0939-5555",
    "1432-0584"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897371",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC31-1245"
    ],
    [
      "openalex",
      "2720|Acute Myeloid Leukemia Research"
    ]
  ],
  "openalex": "W7170419392",
  "pdf_url": "https://europepmc.org/articles/PMC13680519?pdf=render",
  "pmcid": "PMC13680519",
  "pmid": "42897371",
  "published": "2026-07-01",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/ea78fk7hw2pw6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897371",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897371"
    },
    {
      "first_seen": "2026-10-30T13:45:35Z",
      "native_id": "81b810c21d6e404b8ed18ccf5d9ed05b",
      "source": "doaj",
      "url": "https://doi.org/10.1007/s00277-026-07206-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Acute Myeloid Leukemia Research",
      "subfield": "general"
    }
  ],
  "title": "A rare case of acute basophilic leukemia transformed from high risk myelodysplastic syndrome.",
  "title_text": "A rare case of acute basophilic leukemia transformed from high risk myelodysplastic syndrome.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:35Z",
  "url": "https://research.draconitic.com/paper/ea78fk7hw2pw6",
  "venue": "Annals of hematology",
  "versions": []
}