{
  "abstract": "Extranodal NK/T-cell lymphoma (ENKTCL) is a rare aggressive lymphoma whose management is complicated by HIV-1 co-infection due to drug-drug interactions and overlapping toxicities, specifically the convergent hepatorenal and hematological toxicities resulting from the concurrent use of chemotherapeutic regimens and ART. We report a middle-aged HIV-1 positive man (CD4 ⁺ T cells:198/μL, HIV-1 RNA:9.70×10³ copies/mL) with stage IE ENKTCL nasal type, whose initial nasal congestion was repeatedly misdiagnosed as sinusitis. An integrase strand transfer inhibitor-based (INSTIs) ART was unaffordable, and efavirenz was contraindicated by prior allergy, necessitating continuation of lopinavir/ritonavir-based ART despite its CYP3A4 inhibition. A multidisciplinary team guided concurrent therapy with two full-dose cycles of P-GemOxD (gemcitabine, pegaspargase, oxaliplatin, dexamethasone) followed by consolidative radiotherapy (20 fractions). The patient tolerated treatment without grade ≥ 3 adverse events. Post-therapy PET-CT confirmed complete metabolic response, with HIV-1 RNA undetectable. At 9-month follow-up, remission persisted and CD4 ⁺ T cells rose to 255/μL. This case illustrates that an MDT model offers a practical management framework for delivering full-dose P-GemOxD chemotherapy with non-INSTIs when INSTI-based regimens are not accessible. Our experience provides a reference strategy for managing the therapeutic complexities of concurrent HIV and malignancy.",
  "abstract_shown": true,
  "affiliations": [
    "Center of Infectious Diseases, West China Hospital of Sichuan University",
    "Department of Hematology, West China Hospital of Sichuan University",
    "Department of Histology, West China Hospital of Sichuan University"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Junjie Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lingyao Du"
    },
    {
      "affs": [
        1
      ],
      "name": "Tian Dong"
    },
    {
      "affs": [
        2
      ],
      "name": "Sha Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Jie Ji"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong Tang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eacw39qch2r8k.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1954471",
  "fulltext_url": "https://europepmc.org/articles/PMC13683803",
  "id": "eacw39qch2r8k",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1954471/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Viral-associated cancers and disorders"
    ]
  ],
  "openalex": "W7220846268",
  "pdf_url": "https://europepmc.org/articles/PMC13683803?pdf=render",
  "pmcid": "PMC13683803",
  "pmid": "42909113",
  "published": "2026-10-07",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/eacw39qch2r8k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1954471",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1954471/full"
    },
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42909113",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909113"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Viral-associated cancers and disorders",
      "subfield": "oncology"
    }
  ],
  "title": "HIV-associated extranodal NK/T cell lymphoma, nasal type: a case report and literature review",
  "title_text": "HIV-associated extranodal NK/T cell lymphoma, nasal type: a case report and literature review",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/eacw39qch2r8k",
  "venue": "Frontiers in Immunology",
  "versions": []
}