{
  "abstract": "Dietary supplements are widely perceived as safe, yet high-dose ingestion can cause severe toxicity. We report a 20-year-old woman who developed acute hepatocellular injury following intentional ingestion of 15 g nicotinamide. She presented with vomiting, epigastric pain, and transient hypotension. Liver function tests rapidly deteriorated with a marked transaminitis, with associated coagulopathy. There was no hepatic encephalopathy. Extensive investigations for viral, autoimmune, metabolic, and vascular causes were unrevealing. She improved with supportive care, including N-acetylcysteine, vitamin K, and electrolyte replacement. This case highlights nicotinamide overdose as an important and potentially under-recognized cause of severe acute liver injury.",
  "abstract_shown": true,
  "affiliations": [
    "Gastroenterology, Monash Health, Melbourne, Victoria, Australia",
    "College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia",
    "Emergency Medicine, Monash Health, Melbourne, Victoria, Australia"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yousef Hakimi"
    },
    {
      "affs": [
        0
      ],
      "name": "Stefan Uzelac"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Nicholas Wan"
    },
    {
      "affs": [
        0
      ],
      "name": "Natalie Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Nikita Parkash"
    },
    {
      "affs": [
        2
      ],
      "name": "Matthew Brownlow"
    },
    {
      "affs": [
        0
      ],
      "name": "Dilip Ratnam"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/eb1d21xasqw0z.bib",
  "cited_by": 0,
  "doi": "10.14309/crj.0000000000002365",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734553/",
  "id": "eb1d21xasqw0z",
  "issns": [
    "2326-3253"
  ],
  "landing_url": "https://doi.org/10.14309/crj.0000000000002365",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "heading",
      "Liver"
    ],
    [
      "openalex",
      "3004|Drug-Induced Hepatotoxicity and Protection"
    ]
  ],
  "openalex": "W7225267748",
  "pdf_url": null,
  "pmcid": "PMC13734553",
  "pmid": "42985323",
  "published": "2026-11-04",
  "publisher": "American College of Gastroenterology",
  "ris": "https://research.draconitic.com/paper/eb1d21xasqw0z.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:24:00Z",
      "native_id": "PMC13734553",
      "source": "pmc",
      "url": "https://doi.org/10.14309/crj.0000000000002365"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3004|Drug-Induced Hepatotoxicity and Protection",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Nicotinamide as a Cause of Severe Acute Hepatocellular Injury",
  "title_text": "Nicotinamide as a Cause of Severe Acute Hepatocellular Injury",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:24:00Z",
  "url": "https://research.draconitic.com/paper/eb1d21xasqw0z",
  "venue": "ACG Case Reports Journal",
  "versions": []
}