{
  "abstract": "De novo small-cell neuroendocrine prostate cancer (SCNE PC) is a rare and highly aggressive subtype of prostate cancer with limited treatment options. BRCA2 alterations may increase sensitivity to platinum-based chemotherapy and PARP inhibition; however, evidence regarding their clinical relevance in SCNE PC is limited. We present two cases of de novo SCNE PC with distinct BRCA2 alterations. Both patients presented with a similarly extensive disease burden and initially received carboplatin and etoposide (CE), but their clinical courses differed markedly. Patient 1 developed brain metastases three months after completing six cycles of CE and died shortly after rechallenge with CE. In contrast, Patient 2 responded to repeated CE rechallenges, followed by short-term disease control with topotecan and 18 months of disease control with the PARP inhibitor olaparib. He subsequently developed leptomeningeal carcinomatosis and died shortly thereafter, with an overall survival of 5 years and 8 months. These cases illustrate the highly aggressive clinical course of de novo SCNE PC. Despite the potential predictive value of BRCA2 alterations, they may be associated with a higher incidence of brain metastases.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.",
    "Department for Urology, Esbjerg and Grindsted Hospital, University Hospital of Southern Denmark, 6700 Esbjerg, Denmark.",
    "Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.",
    "Department of Pathology, Vejle Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.",
    "Department of Clinical Genetics, Vejle Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.",
    "Department of Radiology and Nuclear Medicine, Esbjerg and Grindsted Hospital, University Hospital of Southern Denmark, 6700 Esbjerg, Denmark."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mads Fallesen Kjer"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Mads Hvid Poulsen",
      "orcid": "0000-0002-7622-8402"
    },
    {
      "affs": [
        3
      ],
      "name": "Sanne Kjær-Frifeldt"
    },
    {
      "affs": [
        4
      ],
      "name": "Marianne Ingerslev Holt",
      "orcid": "0000-0003-0637-9560"
    },
    {
      "affs": [
        5
      ],
      "name": "Mie Holm Vilstrup"
    },
    {
      "affs": [
        0
      ],
      "name": "Ahmed H Zedan",
      "orcid": "0000-0002-8895-6394"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ebp3sryspb93d.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198453",
  "fulltext_url": "https://europepmc.org/articles/PMC13664791",
  "id": "ebp3sryspb93d",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883702",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Prostate Cancer Treatment and Research"
    ]
  ],
  "openalex": "W7214040974",
  "pdf_url": "https://europepmc.org/articles/PMC13664791?pdf=render",
  "pmcid": "PMC13664791",
  "pmid": "42883702",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ebp3sryspb93d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883702",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883702"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Prostate Cancer Treatment and Research",
      "subfield": "general"
    }
  ],
  "title": "The Enemy of My Enemy: Two Cases of De Novo Metastatic Small-Cell Neuroendocrine Prostate Cancer with BRCA2 Alterations and Brain Metastases.",
  "title_text": "The Enemy of My Enemy: Two Cases of De Novo Metastatic Small-Cell Neuroendocrine Prostate Cancer with BRCA2 Alterations and Brain Metastases.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/ebp3sryspb93d",
  "venue": "International journal of molecular sciences",
  "versions": []
}