{ "abstract": "The Computational Barthel Index Tool (CBIT), originally developed using U.S. Department of Veterans Affairs (VA) data, predicts future dependency in activities of daily living up to one year in advance. This study externally validated CBIT in a large non-VA nursing home population and evaluated whether population-specific adaptation could recover performance following external transport. We analyzed SEER-Medicare linked data, including 843,836 patients and over 8 million Minimum Data Set (MDS) assessments. The predictor and outcome structures of the original CBIT models were reconstructed in the SEER-Medicare cohort. Pretrained models were evaluated without modification for discrimination and calibration at current, 3-, 6-, and 12-month prediction timeframes. Population-specific adaptation was evaluated using progressively larger subsets of SEER-Medicare training data and compared with model reconstruction in the SEER-Medicare. Under strict external validation, discrimination declined relative to the original VA models, particularly for longer-term predictions. For evaluation models, mean AUC decreased from 0.795 in the original models to 0.693 at current prediction, 0.595 at 3 months, 0.595 at 6 months, and 0.592 at 12 months. Re-evaluation models showed stronger but similarly declining external performance. Calibration error increased, particularly for evaluation models at longer timeframes. Subgroup analyses showed modest variation in discrimination across demographic and clinical groups. Population-specific adaptation substantially recovered discrimination, with performance improving as more SEER-Medicare training data were incorporated. Using the adaptation training set, adapted models achieved performance comparable to SEER-Medicare model reconstruction. External validation revealed substantial performance degradation when CBIT was transported to a non-VA population. Population-specific adaptation recovered much of this performance loss, supporting a structured approach to clinical ML transportability in which pretrained models are externally validated first, followed by adaptation when performance degradation is observed. Full model reconstruction remains an alternative when sufficient local data are available. Author summary: Machine learning models are increasingly used in healthcare to help predict patient outcomes and support clinical decision-making. However, models developed in one healthcare system may not perform as well when applied to different patient populations. Understanding how performance changes when a model is evaluated in a new population, and whether performance can be recovered without fully redeveloping the model, is important for successful implementation of clinical machine learning. We evaluated the Computational Barthel Index Tool (CBIT), a model developed using U.S. Department of Veterans Affairs (VA) data to predict future dependency in activities of daily living. We tested the model in a non-VA nursing home population of more than 800,000 patients, including millions of clinical assessments. When applied without modification, CBIT performance declined, particularly for longer-term predictions. We then adapted the model using data from the new population and examined how performance changed as increasing amounts of local data were used. Adaptation substantially recovered performance, with greater improvements observed as more local data were incorporated. We also compared adapted models with models reconstructed using local data. These findings suggest that adapting an existing model may provide a practical alternative to full model redevelopment when local data or development resources are limited.", "abstract_shown": true, "affiliations": [ "Department of Health Administration, Policy and Informatics, George Mason University, Fairfax, Virginia, United States of America." ], "article_type": "Research Article", "arxiv": null, "author_total": 5, "authors": [ { "affs": [ 0 ], "name": "Lemba Priscille Ngana", "orcid": "0009-0003-7950-2563" }, { "affs": [ 0 ], "name": "Janusz Wojtusiak" }, { "affs": [ 0 ], "name": "Atefehsadat Haghighathoseini" }, { "affs": [ 0 ], "name": "Bhumi Patel" }, { "affs": [ 0 ], "name": "Dharmi Desai", "orcid": "0009-0005-6038-1073" } ], "bibtex": "https://research.draconitic.com/paper/ebrbfv1g1x22k.bib", "cited_by": 0, "doi": "10.1371/journal.pdig.0001793", "fulltext_url": "https://journals.plos.org/digitalhealth/article?id=10.1371/journal.pdig.0001793", "id": "ebrbfv1g1x22k", "issns": [ "2767-3170" ], "landing_url": "https://journals.plos.org/digitalhealth/article?id=10.1371/journal.pdig.0001793", "language": "eng", "licence": "CC-BY", "licence_label": "CC BY", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "3600|Geriatric Care and Nursing Homes" ], [ "plos", "/Medicine and health sciences/Health care/Health care facilities/Nursing homes" ], [ "plos", "/Medicine and health sciences/Health care/Health care providers/Allied health care professionals" ], [ "plos", "/Medicine and health sciences/Health care/Quality of life/Activities of daily living" ], [ "plos", "/Medicine and health sciences/Oncology/Cancers and neoplasms" ], [ "plos", "/Medicine and health sciences/Oncology/Cancers and neoplasms/Breast tumors/Breast cancer" ], [ "plos", "/Medicine and health sciences/Oncology/Cancers and neoplasms/Gastrointestinal tumors/Pancreatic cancer" ], [ "plos", "/Medicine and health sciences/Oncology/Cancers and neoplasms/Genitourinary tract tumors/Prostate cancer" ], [ "plos", "/Medicine and health sciences/Oncology/Cancers and neoplasms/Lung and intrathoracic tumors" ], [ "plos", "/Medicine and health sciences/Urology/Prostate diseases/Prostate cancer" ] ], "openalex": "W7223281619", "pdf_url": "https://journals.plos.org/digitalhealth/article/file?id=10.1371/journal.pdig.0001793&type=printable", "pmcid": "PMC13693907", "pmid": "42912734", "published": "2026-10-23", "publisher": "Public Library of Science", "ris": "https://research.draconitic.com/paper/ebrbfv1g1x22k.ris", "sources": [ { "first_seen": "2026-10-30T12:17:17Z", "native_id": "10.1371/journal.pdig.0001793", "source": "plos", "url": "https://journals.plos.org/digitalhealth/article?id=10.1371/journal.pdig.0001793" }, { "first_seen": "2026-10-30T12:20:10Z", "native_id": "MED:42912734", "source": "europepmc", "url": "https://europepmc.org/article/MED/42912734" } ], "subjects": [ { "field": "medicine", "origin": "plos:cancers and neoplasms", "subfield": "oncology" } ], "title": "External validation and adaptation of the Computational Barthel Index Tool in a large nursing home cohort", "title_text": "External validation and adaptation of the Computational Barthel Index Tool in a large nursing home cohort", "type": "peer-reviewed", "updated_at": "2026-10-30T12:20:10Z", "url": "https://research.draconitic.com/paper/ebrbfv1g1x22k", "venue": "PLOS Digital Health", "versions": [] }