{
  "abstract": "Background: The objective of this research is to determine the relative abundances and clinical significance of the long non-coding RNA (lncRNA) RASAL2-AS1 in cervical cancer. Additionally, this study aims to elucidate its molecular mechanism in influencing malignant progression through the regulation of the microRNA-590-5p (miR-590-5p)/PDCD5 axis and the Wnt/β-catenin signaling pathway.\n\nMethods: Gene expression of RASAL2-AS1 was assessed in cervical cancer tissues (n = 103) using quantitative real-time PCR (qRT-PCR). The impacts on cellular events, epithelial-mesenchymal transition (EMT), and key signaling pathways were evaluated using CCK-8, Transwell, and Western Blot techniques. The target relationships among RASAL2-AS1, miR-590-5p, and PDCD5 were verified via luciferase reporter assays.\n\nResults: RASAL2-AS1 exhibited significantly reduced expression in cervical cancer. Its downregulation was markedly associated with advanced FIGO staging (P = 0.014), lymph node metastasis (P = 0.035), and poor prognosis, establishing it as an independent indicator of unfavorable outcomes for cervical cancer patients (HR = 0.201, 95% CI = 0.087–0.464, P < 0.001). Functionally, the upregulation of RASAL2-AS1 inhibited cervical cancer cell growth and EMT. Mechanistically, RASAL2-AS1 acted as a molecular sponge to sequester miR-590-5p, thereby alleviating its inhibitory effect on PDCD5. Furthermore, RASAL2-AS1 obstructs the Wnt/β-catenin pathway through the miR-590-5p/PDCD5 axis.\n\nConclusions: RASAL2-AS1 exerts a tumor-suppressive effect in cervical cancer by functioning as a competing endogenous RNA (ceRNA) that modulates the miR-590-5p/PDCD5 axis and regulates the Wnt/β-catenin pathway.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Affiliated Women’s Hospital of Jiangnan University (Wuxi Woman and Enfants Care Hospital), Wuxi, 214000 China",
    "Department of Obstetrics and Gynecology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201699 China",
    "Department of Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, No. 123, Tianfei Lane, Mochou Road, Qinhuai District, Nanjing, Jiangsu Province 210004 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ke Yin"
    },
    {
      "affs": [
        1
      ],
      "name": "Yi Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Mengying Tang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ebwjmzhbk4egy.bib",
  "cited_by": 0,
  "doi": "10.1186/s41065-026-00709-3",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13712019/",
  "id": "ebwjmzhbk4egy",
  "issns": [
    "0018-0661",
    "1601-5223"
  ],
  "landing_url": "https://doi.org/10.1186/s41065-026-00709-3",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "1306|Cancer-related molecular mechanisms research"
    ]
  ],
  "openalex": "W7171495119",
  "pdf_url": null,
  "pmcid": "PMC13712019",
  "pmid": "42934817",
  "published": "2026-07-28",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/ebwjmzhbk4egy.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:41Z",
      "native_id": "PMC13712019",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s41065-026-00709-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer-related molecular mechanisms research",
      "subfield": "oncology"
    }
  ],
  "title": "LncRNA RASAL2-AS1 serves as a potential biomarker for prognosis and regulates cellular processes via the miR-590-5p/PDCD5 axis and Wnt/β-catenin pathway in cervical cancer",
  "title_text": "LncRNA RASAL2-AS1 serves as a potential biomarker for prognosis and regulates cellular processes via the miR-590-5p/PDCD5 axis and Wnt/β-catenin pathway in cervical cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:41Z",
  "url": "https://research.draconitic.com/paper/ebwjmzhbk4egy",
  "venue": "Hereditas",
  "versions": []
}